1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile 2,2,2-trifluoroacetate

Base Information

Chemical Name:1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile 2,2,2-trifluoroacetate
CAS No.:1315462-57-7
Molecular Formula:C₂HF₃O₂*C₂₁H₂₁F₃N₆O
Molecular Weight:544.456
Hs Code.:

Synonyms:1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile 2,2,2-trifluoroacetate

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Chemical Property of 1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile 2,2,2-trifluoroacetate

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Technology Process of 1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile 2,2,2-trifluoroacetate

There total 9 articles about 1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1315464-87-9
tert-butyl 4-(2-(4-(4-cyano-1-methyl-1H-[1,2,3]-triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethyl)piperidine-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 1315462-57-7
1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile 2,2,2-trifluoroacetate

Guidance literature:: In dichloromethane; acetonitrile; at 20 ℃; for 0.166667h;

Reference yield:

: 50824-04-9
4-bromo-2-(trifluoromethyl)phenol

: 1315462-57-7
1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 20.25 h / 0 - 20 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 3 h / 80 °C / Inert atmosphere

3: tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere

4: hydrogenchloride; sodium nitrite / 1-methyl-pyrrolidin-2-one; water / 1.03 h / 5 - 20 °C

5: dichloromethane; acetonitrile / 0.17 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; potassium acetate; triphenylphosphine; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 944388-71-0
4-amino-6-chloro-3-nitropyridine-2-carbonitrile

: 1315462-57-7
1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile / 5 h / 80 °C

2: tin(II) chloride dihdyrate / ethanol / 3 h / 20 °C

3: tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere

4: hydrogenchloride; sodium nitrite / 1-methyl-pyrrolidin-2-one; water / 1.03 h / 5 - 20 °C

5: dichloromethane; acetonitrile / 0.17 h / 20 °C

With hydrogenchloride; tin(II) chloride dihdyrate; potassium carbonate; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; acetonitrile;