Technology Process of (S)-methyl 3-(4-(2-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethyl)piperidin-1-yl)-2-hydroxypropanoate
There total 10 articles about (S)-methyl 3-(4-(2-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethyl)piperidin-1-yl)-2-hydroxypropanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
methanol;
at 100 ℃;
for 0.166667h;
Microwaves;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 20.25 h / 0 - 20 °C
2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 3 h / 80 °C / Inert atmosphere
3: tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere
4: hydrogenchloride; sodium nitrite / 1-methyl-pyrrolidin-2-one; water / 1.03 h / 5 - 20 °C
5: dichloromethane; acetonitrile / 0.17 h / 20 °C
6: N-ethyl-N,N-diisopropylamine / methanol / 0.17 h / 100 °C / Microwaves
With
hydrogenchloride; di-isopropyl azodicarboxylate; potassium acetate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium nitrite;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine;
In
1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium carbonate / acetonitrile / 5 h / 80 °C
2: tin(II) chloride dihdyrate / ethanol / 3 h / 20 °C
3: tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere
4: hydrogenchloride; sodium nitrite / 1-methyl-pyrrolidin-2-one; water / 1.03 h / 5 - 20 °C
5: dichloromethane; acetonitrile / 0.17 h / 20 °C
6: N-ethyl-N,N-diisopropylamine / methanol / 0.17 h / 100 °C / Microwaves
With
hydrogenchloride; tin(II) chloride dihdyrate; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium nitrite;
tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine;
In
1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; acetonitrile;