Chemical Property of Hydron;3-phenyldiazenylpyridine-2,6-diamine;chloride
Chemical Property:
- Appearance/Colour:brick-red crystals
- Vapor Pressure:5.66E-09mmHg at 25°C
- Melting Point:139 ºC
- Refractive Index:1.6110 (estimate)
- Boiling Point:442.3 ºC at 760 mmHg
- Flash Point:221.3 ºC
- PSA：89.65000
- Density:1.2645 (rough estimate)
- LogP:4.62580
- Storage Temp.:Amber Vial, -20°C Freezer
- Solubility.:DMSO (Slightly, Heated), Methanol (Slightly, Heated)
- Water Solubility.:0.01-0.1 g/100 mL at 20 ºC
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:2
- Exact Mass:249.0781231
- Heavy Atom Count:17
- Complexity:237
- Purity/Quality:
-
99% *data from raw suppliers
Phenazopyridine hydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn,
C
- Hazard Codes:Xn,C
- Statements:
22-36/37/38-40-34-42/43
- Safety Statements:
26-36/37-45-36/37/39-27-22
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:[H+].C1=CC=C(C=C1)N=NC2=C(N=C(C=C2)N)N.[Cl-]
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Description
Phenazopyridine is an azo dye with analgesic properties. It decreases the bladder distension-induced firing rate of afferent bladder Aγ-fibers, but not C-fibers, in anesthetized rats when administered at a doses of 0.3, 1, and 3 mg/kg. Formulations containing phenazopyridine have been used as analgesics in the treatment of urinary tract infections.
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Uses
An azo dye used in treatment of urinary tract infections. Used as an analgesic (urinary tract). anticonvulsant, antieleptic therapeutic for urinary tract infections Phenazopyridine hydrochloride has been used for 50 years as an analgesic drug either alone or in combination with other drugs to reduce pain associated with urinary tract infection. An azo dye used in urinary tract infections. Also used as a local anesthetic. Exposure to phenazopyridine hydrochloride occurs during manufacture and formulation.
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Therapeutic Function
Urinary analgesic, Antiseptic, Diagnostic aid
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Clinical Use
Phenazopyridine hydrochloride, 2,6-diamino-3-(phenylazopyridinehydrochloride (Pyridium), is a brick-red, finecrystalline powder. It is slightly soluble in alcohol, in chloroform,and in water.Phenazopyridine hydrochloride was formerly used asa urinary antiseptic. Although it is active in vitro againststaphylococci, streptococci, gonococci, and E. coli, it has nouseful antibacterial activity in the urine. Thus, its presentutility lies in its local analgesic effect on the mucosa of theurinary tract.Usually, phenazopyridine is given in combination withurinary antiseptics. For example, it is available as Azo-Gantrisin, a fixed-dose combination with the sulfonamide antibacterialsulfisoxazole, and as Urobiotic, a combination withthe antibiotic oxytetracycline and the sulfonamide sulfamethizole. The drug is rapidly excreted in the urine, towhich it gives an orange-red color. Stains in fabrics may beremoved by soaking in a 0.25% solution of sodium dithionite.
