Hydron;3-phenyldiazenylpyridine-2,6-diamine;chloride

Base Information

• Chemical Name: Hydron;3-phenyldiazenylpyridine-2,6-diamine;chloride
• CAS No.: 136-40-3
• Molecular Formula: C11H11N5^.HCl
• Molecular Weight: 249.703
• Hs Code.: 29333990
• Mol file: 136-40-3.mol

Synonyms:AKOS026750097

Chemical Property of Hydron;3-phenyldiazenylpyridine-2,6-diamine;chloride

Chemical Property:

• Appearance/Colour: brick-red crystals
• Vapor Pressure: 5.66E-09mmHg at 25°C
• Melting Point: 139 ºC
• Refractive Index: 1.6110 (estimate)
• Boiling Point: 442.3 ºC at 760 mmHg
• Flash Point: 221.3 ºC
• PSA: 89.65000
• Density: 1.2645 (rough estimate)
• LogP: 4.62580
• Storage Temp.: Amber Vial, -20°C Freezer
• Solubility.: DMSO (Slightly, Heated), Methanol (Slightly, Heated)
• Water Solubility.: 0.01-0.1 g/100 mL at 20 ºC
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 249.0781231
• Heavy Atom Count: 17
• Complexity: 237

Purity/Quality:

99% ^*data from raw suppliers

Phenazopyridine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,C
• Hazard Codes: Xn,C
• Statements: 22-36/37/38-40-34-42/43
• Safety Statements: 26-36/37-45-36/37/39-27-22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: [H+].C1=CC=C(C=C1)N=NC2=C(N=C(C=C2)N)N.[Cl-]
• Description: Phenazopyridine is an azo dye with analgesic properties. It decreases the bladder distension-induced firing rate of afferent bladder Aγ-fibers, but not C-fibers, in anesthetized rats when administered at a doses of 0.3, 1, and 3 mg/kg. Formulations containing phenazopyridine have been used as analgesics in the treatment of urinary tract infections.
• Uses: An azo dye used in treatment of urinary tract infections. Used as an analgesic (urinary tract). anticonvulsant, antieleptic therapeutic for urinary tract infections Phenazopyridine hydrochloride has been used for 50 years as an analgesic drug either alone or in combination with other drugs to reduce pain associated with urinary tract infection. An azo dye used in urinary tract infections. Also used as a local anesthetic. Exposure to phenazopyridine hydrochloride occurs during manufacture and formulation.
• Therapeutic Function: Urinary analgesic, Antiseptic, Diagnostic aid
• Clinical Use: Phenazopyridine hydrochloride, 2,6-diamino-3-(phenylazopyridinehydrochloride (Pyridium), is a brick-red, finecrystalline powder. It is slightly soluble in alcohol, in chloroform,and in water.Phenazopyridine hydrochloride was formerly used asa urinary antiseptic. Although it is active in vitro againststaphylococci, streptococci, gonococci, and E. coli, it has nouseful antibacterial activity in the urine. Thus, its presentutility lies in its local analgesic effect on the mucosa of theurinary tract.Usually, phenazopyridine is given in combination withurinary antiseptics. For example, it is available as Azo-Gantrisin, a fixed-dose combination with the sulfonamide antibacterialsulfisoxazole, and as Urobiotic, a combination withthe antibiotic oxytetracycline and the sulfonamide sulfamethizole. The drug is rapidly excreted in the urine, towhich it gives an orange-red color. Stains in fabrics may beremoved by soaking in a 0.25% solution of sodium dithionite.

Technology Process of Hydron;3-phenyldiazenylpyridine-2,6-diamine;chloride

There total 2 articles about Hydron;3-phenyldiazenylpyridine-2,6-diamine;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2.6-diaminopyridine (141-86-6) + aniline (62-53-3) → 3-phenyldiazenylpyridine-2,6-diamine monohydrochloride (136-40-3)

Guidance literature:

With hydrogenchloride; sodium nitrite; Yield given. Multistep reaction; 1) 10 min, ice-cooled, 2) r. t., 20 min;

Reference yield:

2.6-diaminopyridine (141-86-6) + benzene diazonium chloride (100-34-5) → 3-phenylazo-pyridine-2,6-diyldiamine; dihydrochloride (136-40-3,10393-51-8)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01323a018

Reference yield: 92.0%

3-phenyldiazenylpyridine-2,6-diamine monohydrochloride (136-40-3) → pyridium (94-78-0)

Guidance literature:

With potassium carbonate; In water; ethyl acetate; at 20 ℃; for 0.5h;

upstream raw materials:

2.6-diaminopyridine

benzene diazonium chloride

aniline

Downstream raw materials:

Blue Fluorophor

pyridium

C₈H₅NO₂*C₁₁H₁₁N₅

C₈H₈O₃*C₁₁H₁₁N₅

Refernces