9-<(S)-2-amino-3-phenylpropionyl>-2-(2-fluorophenyl)-7,8,9,10-tetrahydropyrido<3,4-e><1,2,4>triazolo<1,5-c>pyrimidin-5(6H)-one hydrochloride

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Chemical Name:9-<(S)-2-amino-3-phenylpropionyl>-2-(2-fluorophenyl)-7,8,9,10-tetrahydropyrido<3,4-e><1,2,4>triazolo<1,5-c>pyrimidin-5(6H)-one hydrochloride
CAS No.:135481-45-7
Molecular Formula:C₂₃H₂₁FN₆O₂*ClH
Molecular Weight:468.918
Hs Code.:

Synonyms:9-<(S)-2-amino-3-phenylpropionyl>-2-(2-fluorophenyl)-7,8,9,10-tetrahydropyrido<3,4-e><1,2,4>triazolo<1,5-c>pyrimidin-5(6H)-one hydrochloride

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Chemical Property of 9-<(S)-2-amino-3-phenylpropionyl>-2-(2-fluorophenyl)-7,8,9,10-tetrahydropyrido<3,4-e><1,2,4>triazolo<1,5-c>pyrimidin-5(6H)-one hydrochloride

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Technology Process of 9-<(S)-2-amino-3-phenylpropionyl>-2-(2-fluorophenyl)-7,8,9,10-tetrahydropyrido<3,4-e><1,2,4>triazolo<1,5-c>pyrimidin-5(6H)-one hydrochloride

There total 7 articles about 9-<(S)-2-amino-3-phenylpropionyl>-2-(2-fluorophenyl)-7,8,9,10-tetrahydropyrido<3,4-e><1,2,4>triazolo<1,5-c>pyrimidin-5(6H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 135481-51-5
{(S)-1-Benzyl-2-[2-(2-fluoro-phenyl)-4-oxo-5,6,7,9-tetrahydro-4H-1,3,3a,5,8-pentaaza-cyclopenta[a]naphthalen-8-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester

: 135481-45-7
9-<(S)-2-amino-3-phenylpropionyl>-2-(2-fluorophenyl)-7,8,9,10-tetrahydropyrido<3,4-e><1,2,4>triazolo<1,5-c>pyrimidin-5(6H)-one hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; dichloromethane; at 35 ℃;
DOI:10.1021/jm00113a032

Reference yield:

: 111-94-4
3,3'-Iminodipropionitrile

: 135481-45-7
9-<(S)-2-amino-3-phenylpropionyl>-2-(2-fluorophenyl)-7,8,9,10-tetrahydropyrido<3,4-e><1,2,4>triazolo<1,5-c>pyrimidin-5(6H)-one hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: KOt-Bu / 2-methyl-propan-2-ol

2: 79 percent / sodium bicarbonate / butan-2-one / 2 h

3: NaOEt / ethanol / 2 h / 110 °C

4: 26 percent / tri-n-propylamine / 2-methoxy-ethanol / 16 h / Heating

5: 1.) 4 N NaOH, 2.) aq. HCl / 1.) methoxyethanol, 120 deg C, overnight

6: 1.) N,N'-carbonyldiimidazole / 1.) 30 min, 2.) RT, 18 h

7: 78 percent / 3 N etheral HCl / methanol; CH₂Cl₂ / 35 °C

With hydrogenchloride; tri-n-propylamine; sodium hydroxide; potassium tert-butylate; sodium ethanolate; sodium hydrogencarbonate; 1,1'-carbonyldiimidazole; In methanol; ethanol; dichloromethane; 2-methoxy-ethanol; butanone; tert-butyl alcohol;
DOI:10.1021/jm00113a032

Reference yield:

: 15827-80-2
4-amino-3-cyano-1,2,5,6-tetrahydropyridine

: 135481-45-7
9-<(S)-2-amino-3-phenylpropionyl>-2-(2-fluorophenyl)-7,8,9,10-tetrahydropyrido<3,4-e><1,2,4>triazolo<1,5-c>pyrimidin-5(6H)-one hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 79 percent / sodium bicarbonate / butan-2-one / 2 h

2: NaOEt / ethanol / 2 h / 110 °C

3: 26 percent / tri-n-propylamine / 2-methoxy-ethanol / 16 h / Heating

4: 1.) 4 N NaOH, 2.) aq. HCl / 1.) methoxyethanol, 120 deg C, overnight

5: 1.) N,N'-carbonyldiimidazole / 1.) 30 min, 2.) RT, 18 h

6: 78 percent / 3 N etheral HCl / methanol; CH₂Cl₂ / 35 °C

With hydrogenchloride; tri-n-propylamine; sodium hydroxide; sodium ethanolate; sodium hydrogencarbonate; 1,1'-carbonyldiimidazole; In methanol; ethanol; dichloromethane; 2-methoxy-ethanol; butanone;
DOI:10.1021/jm00113a032