tert-butyl N-tert-butoxycarbonyl-N-(6-fluoro-3-hydroxy-2-methyl-phenyl)carbamate

Base Information

Chemical Name:tert-butyl N-tert-butoxycarbonyl-N-(6-fluoro-3-hydroxy-2-methyl-phenyl)carbamate
CAS No.:1427407-16-6
Molecular Formula:C₁₇H₂₄FNO₅
Molecular Weight:341.38
Hs Code.:

Synonyms:tert-butyl N-tert-butoxycarbonyl-N-(6-fluoro-3-hydroxy-2-methyl-phenyl)carbamate

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Chemical Property of tert-butyl N-tert-butoxycarbonyl-N-(6-fluoro-3-hydroxy-2-methyl-phenyl)carbamate

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Technology Process of tert-butyl N-tert-butoxycarbonyl-N-(6-fluoro-3-hydroxy-2-methyl-phenyl)carbamate

There total 5 articles about tert-butyl N-tert-butoxycarbonyl-N-(6-fluoro-3-hydroxy-2-methyl-phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1427407-15-5
tert-butyl N-tert-butoxycarbonyl-N-[6-fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate

: 1427407-16-6
tert-butyl N-tert-butoxycarbonyl-N-(6-fluoro-3-hydroxy-2-methyl-phenyl)carbamate

Guidance literature:: With water; dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

Reference yield:

: 1227210-35-6
1-bromo-4-fluoro-2-methyl-3-nitro-benzene

: 1427407-16-6
tert-butyl N-tert-butoxycarbonyl-N-(6-fluoro-3-hydroxy-2-methyl-phenyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: iron; ammonium chloride / ethanol / 3 h / Reflux

2: dmap; triethylamine / N,N-dimethyl-formamide

3: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 4 h / 80 °C / Inert atmosphere

4: dihydrogen peroxide; water; sodium hydroxide / tetrahydrofuran / 3 h / 0 - 20 °C

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; dihydrogen peroxide; potassium acetate; iron; ammonium chloride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 3013-27-2
1-fluoro-3-methyl-2-nitro-benzene

: 1427407-16-6
tert-butyl N-tert-butoxycarbonyl-N-(6-fluoro-3-hydroxy-2-methyl-phenyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid; N-Bromosuccinimide / 2 h / 20 °C

2: iron; ammonium chloride / ethanol / 3 h / Reflux

3: dmap; triethylamine / N,N-dimethyl-formamide

4: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 4 h / 80 °C / Inert atmosphere

5: dihydrogen peroxide; water; sodium hydroxide / tetrahydrofuran / 3 h / 0 - 20 °C

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; sulfuric acid; water; dihydrogen peroxide; potassium acetate; iron; ammonium chloride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;