1-Azido-2-nitro-4-trifluoromethoxy-benzene

Base Information

• Chemical Name: 1-Azido-2-nitro-4-trifluoromethoxy-benzene
• CAS No.: 1025801-23-3
• Molecular Formula: C₇H₃F₃N₄O₃
• Molecular Weight: 248.121
• Mol file: 1025801-23-3.mol

Synonyms:1-Azido-2-nitro-4-trifluoromethoxy-benzene

Chemical Property of 1-Azido-2-nitro-4-trifluoromethoxy-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Azido-2-nitro-4-trifluoromethoxy-benzene

There total 4 articles about 1-Azido-2-nitro-4-trifluoromethoxy-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(trifluoromethoxy)aniline (461-82-5) → 1-Azido-2-nitro-4-trifluoromethoxy-benzene (1025801-23-3)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid / 0.25 h / Heating

2: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min

3: conc. sulfuric acid / 0.25 h / 100 °C

4: 1.) aq. HCl, NaNO₂, 2.) aq. NaN₃, sodium acetate / 1.) 0 deg C, 15 min

With hydrogenchloride; sodium azide; sulfuric acid; nitric acid; sodium acetate; sodium nitrite; In acetic acid;

DOI:10.1021/jm00010a023

Reference yield:

2-nitro-4-trifluoromethoxyaniline (2267-23-4) → 1-Azido-2-nitro-4-trifluoromethoxy-benzene (1025801-23-3)

Guidance literature:

With hydrogenchloride; sodium azide; sodium acetate; sodium nitrite; Yield given. Multistep reaction; 1.) 0 deg C, 15 min;

DOI:10.1021/jm00010a023

Reference yield:

N-(4-(trifluoromethoxy)phenyl)acetamide (1737-06-0) → 1-Azido-2-nitro-4-trifluoromethoxy-benzene (1025801-23-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min

2: conc. sulfuric acid / 0.25 h / 100 °C

3: 1.) aq. HCl, NaNO₂, 2.) aq. NaN₃, sodium acetate / 1.) 0 deg C, 15 min

With hydrogenchloride; sodium azide; sulfuric acid; nitric acid; sodium acetate; sodium nitrite;

DOI:10.1021/jm00010a023

upstream raw materials:

2-nitro-4-trifluoromethoxyaniline

4-(trifluoromethoxy)aniline

N-(4-(trifluoromethoxy)phenyl)acetamide

2-nitro-4-trifluoromethoxy-N-acetylaniline