1737-06-0

Basic information

• Product Name: 4'-(TRIFLUOROMETHOXY)ACETANILIDE
• Synonyms: N1-[4-(TRIFLUOROMETHOXY)PHENYL]ACETAMIDE;4'-(TRIFLUOROMETHOXY)ACETANILIDE;4-(TRIFLUOROMETHOXY)ACETANILIDE;4'-(Trifluoromethoxy)acetanilide 97%;4'-(Trifluoromethoxy)acetanilide97%;N-(4-(trifluoroMethoxy)phenyl)acetaMide
• CAS NO: 1737-06-0
• Molecular Formula: C₉H₈F₃NO₂
• Molecular Weight: 219.16
• Mol File: 1737-06-0.mol
• Article Data: 14

Chemical Properties

• Melting Point: 115-117°C
• Boiling Point: 296.8 °C at 760 mmHg
• Flash Point: 133.3 °C
• Appearance: /
• Density: 1.345 g/cm³
• Vapor Pressure: 0.00141mmHg at 25°C
• Refractive Index: 1.496
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.14±0.70(Predicted)
• CAS DataBase Reference: 4'-(TRIFLUOROMETHOXY)ACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-(TRIFLUOROMETHOXY)ACETANILIDE(1737-06-0)
• EPA Substance Registry System: 4'-(TRIFLUOROMETHOXY)ACETANILIDE(1737-06-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 1737-06-0(Hazardous Substances Data)

Usage

General Description

4'-(Trifluoromethoxy)acetanilide is a chemical compound with the molecular formula C9H8F3NO2. It is an acetanilide derivative with a trifluoromethoxy group attached to the para position of the phenyl ring. 4'-(TRIFLUOROMETHOXY)ACETANILIDE is commonly used as an intermediate in organic synthesis and in the pharmaceutical industry for the preparation of various pharmaceutical drugs. It is also used as a reagent in chemical reactions and as a building block for the synthesis of other organic compounds. Additionally, 4'-(Trifluoromethoxy)acetanilide has been studied for its potential biological and pharmacological activities, making it a versatile and important chemical in various scientific and industrial applications.

InChI:InChI=1/C9H8F3NO2/c1-6(14)13-7-2-4-8(5-3-7)15-9(10,11)12/h2-5H,1H3,(H,13,14)

Upstream product

• 461-82-5 4-(trifluoromethoxy)aniline 
• 75-36-5 acetyl chloride 
• 1265612-59-6 (E)-1-(4-(trifluoromethoxy)phenyl)ethan-1-one oxime 
• 42823-24-5 4-(trifluoromethoxy)aniline hydrochloride 
• 60-35-5 acetamide 
• 127-19-5 N,N-dimethyl acetamide 
• 100-65-2 N-Phenylhydroxylamine 
• 887144-94-7 Togni's reagent II 
• 1795-83-1 N-Phenylacetohydroxamic acid 
• 98-95-3 nitrobenzene 
• 456-71-3 4-trifluoromethoxybenzamide 
• 332-25-2 4-(trifluoromethoxy)benzonitrile 
• 36823-89-9 4-(Trichloromethoxy)benzoyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 256529-43-8 N-(2-chloro-4-(trifluoromethoxy)phenyl)acetamide 
• 175278-20-3 N-ethyl-4-(trifluoromethoxy)aniline 
• 658-89-9 4-(trifluoromethoxy)benzene-1,2-diamine 
• 877681-12-4 5-(trifluoromethoxy)-1,3-dihydro-2H-benzo[d]imidazol-2-one 
• 1351534-24-1 (2R)-2-[2-chloro-5-[[3-(6-methoxybenzisoxazol-3-yl)-2-oxo-5-trifluoromethoxybenzimidazol-1-yl]methyl]phenoxy]propanoic acid 
• 1351534-05-8 2-amino-4-trifluoromethoxy-N-acetylaniline 
• 142621-14-5 N-(4-trifluoromethoxyphenyl)-p-toluidine 
• 1025801-23-3 1-Azido-2-nitro-4-trifluoromethoxy-benzene 
• 2267-23-4 2-nitro-4-trifluoromethoxyaniline 
• 787-57-5 2-nitro-4-trifluoromethoxy-N-acetylaniline 
• 399-20-2 2-methyl-6-(trifluoromethoxy)benzo[d]thiazole 

Relevant articles and documents

Copper-promoted difunctionalization of unactivated alkenes with silanes

An efficient copper-catalyzed cascade difunctionalization of N-allyl anilines toward the synthesis of silylated indolines using commercially available silanes has been reported. This strategy provides a new avenue for the synthesis of a diverse array of i

An Environmentally Benign, Catalyst-Free N?C Bond Cleavage/Formation of Primary, Secondary, and Tertiary Unactivated Amides

Herein, we report an operationally simple, cheap, and catalyst-free method for the transamidation of a diverse range of unactivated amides furnishing the desired products in excellent yields. This protocol is environmentally friendly and operates under extremely mild conditions without using any promoter or additives. Significantly, this strategy has been implied in the chemoselective synthesis of a pharmaceutical molecule, paracetamol, on a gram-scale with excellent yield. We anticipate that this universally applicable strategy will be of great interest in drug discovery, biochemistry, and organic synthesis.

TRIFLUOROMETHOXYLATION OF ARENES VIA INTRAMOLECULAR TRIFLUOROMETHOXY GROUP MIGRATION

The present invention provides a process of producing a trifluoromethoxylated aryl or trifluoromethoxylated heteroaryl having the structure: (I), wherein A is an aryl or heteroaryl, each with or without subsutitution; and R1 is -H, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), - (alkylaryl), - (alkylheteroaryl), -NH-(alkyl), -N(alkyl)2, -NH-(alkenyl), -NH-(alkynyl) -NH-(aryl), -NH-(heteroaryl), -O-(alkyl), -O-(alkenyl), -O-(alkynyl), -O-(aryl), -O-(heteroaryl), -S-(alkyl), -S- (alkenyl), -S-(alkynyl), -S-(aryl), or -S-(heteroaryl), comprising: (a) reacting a compound having the structure: (II), with a trifluoromethylating agent in the presence of a base in a first suitable solvent under conditions to produce a compound having the structure: (III); and (b) maintaining the compound produced in step (a) in a second suitable solvent under conditions sufficient to produce the trifluoromethoxylated aryl or trifluormethoxylated heteroaryl having the structure: (I).