17α-benzoyloxy-21-chloro-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

Base Information

Chemical Name:17α-benzoyloxy-21-chloro-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-dione
CAS No.:85198-34-1
Molecular Formula:C₂₉H₃₃ClO₅
Molecular Weight:497.031
Hs Code.:

Synonyms:17α-benzoyloxy-21-chloro-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

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Chemical Property of 17α-benzoyloxy-21-chloro-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

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Technology Process of 17α-benzoyloxy-21-chloro-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

There total 4 articles about 17α-benzoyloxy-21-chloro-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.2%

: 85198-29-4
6α-methylprednisolone-17α,21-methyl orthobenzoate

: 85198-34-1
17α-benzoyloxy-21-chloro-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

Guidance literature:: With phenyl chloroformate; In N,N-dimethyl-formamide; at 80 - 90 ℃; for 0.5h;
DOI:10.1248/cpb.31.12

Reference yield:

: 707-07-3
orthobenzoic acid trimethyl ester

: 85198-34-1
17α-benzoyloxy-21-chloro-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) p-toluenesulfonic acid, 2.) 10percent Na₂CO₃ / 1.) DMF, 70-90 deg C, 2.) DMF, water, ethyl acetate

2: 51.2 percent / phenyl chloroformate / dimethylformamide / 0.5 h / 80 - 90 °C

With sodium carbonate; toluene-4-sulfonic acid; phenyl chloroformate; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.31.12

Reference yield:

: 103744-18-9
(6S,8S,9S,10R,11S,13S,14S,17S)-11-Hydroxy-17-(2-hydroxy-acetyl)-6,10,13-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one

: 85198-34-1
17α-benzoyloxy-21-chloro-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / p-toluenesulfonic acid / dimethylformamide / 1.5 h / 85 °C

2: 50 percent / xanthene-9-carbonyl chloride / dimethylformamide / 0.5 h / 80 °C

With 9H-xanthene-9-carbonyl chloride; toluene-4-sulfonic acid; In N,N-dimethyl-formamide;
DOI:10.1055/s-1982-30048