tert-butyl {(1R)-1-[({[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}amino)carbonyl]-2-methylpropyl}carbamate

Base Information

Chemical Name:tert-butyl {(1R)-1-[({[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}amino)carbonyl]-2-methylpropyl}carbamate
CAS No.:870893-69-9
Molecular Formula:C₃₁H₃₇FN₈O₆
Molecular Weight:636.683
Hs Code.:

tert-butyl {(1R)-1-[({[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}amino)carbonyl]-2-methylpropyl}carbamate

Synonyms:tert-butyl {(1R)-1-[({[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}amino)carbonyl]-2-methylpropyl}carbamate

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Chemical Property of tert-butyl {(1R)-1-[({[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}amino)carbonyl]-2-methylpropyl}carbamate

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Technology Process of tert-butyl {(1R)-1-[({[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}amino)carbonyl]-2-methylpropyl}carbamate

There total 16 articles about tert-butyl {(1R)-1-[({[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}amino)carbonyl]-2-methylpropyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 870893-58-6
(5R)-3-(4-{6-[(5S)-5-(aminomethyl)-4,5-dihydroisoxazol-3-yl]pyridin-3-yl}-3-fluorophenyl)-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one

: 22838-58-0
Boc-D-Val-OH

: 870893-69-9
tert-butyl {(1R)-1-[({[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}amino)carbonyl]-2-methylpropyl}carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 2h;

Reference yield:

: 501939-95-3
(5R)-3-(3-fluoro-4-iodophenyl)-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one

: 870893-69-9
tert-butyl {(1R)-1-[({[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}amino)carbonyl]-2-methylpropyl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 0.67 h / 80 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide); water / 1 h / 85 °C

3: hydrogenchloride / 1,4-dioxane; DMF (N,N-dimethyl-formamide) / 18 h

4: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2 h / 20 °C

With hydrogenchloride; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); water; dimethyl sulfoxide;

Reference yield:

: acetic acid (5R)-3-(3-fluoro-4-iodophenyl)-2-oxooxazolidin-5-ylmethyl ester

: 870893-69-9
tert-butyl {(1R)-1-[({[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}amino)carbonyl]-2-methylpropyl}carbamate

Guidance literature:: Multi-step reaction with 8 steps

1: methanol; potassium carbonate / dichloromethane / 0.42 h / 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C

3: sodium azide / DMF (N,N-dimethyl-formamide) / 75 °C

4: 1,4-dioxane / 100 °C

5: triethylamine / trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane / 1.5 h / 100 °C

6: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide); water / 1 h / 85 °C

7: hydrogenchloride / 1,4-dioxane; DMF (N,N-dimethyl-formamide) / 18 h

8: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2 h / 20 °C

With hydrogenchloride; methanol; sodium azide; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trans-bis(triphenylphosphine)palladium dichloride; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); dichloromethane; water;