(5R)-3-(4-{6-[(5S)-5-(aminomethyl)-4,5-dihydroisoxazol-3-yl]pyridin-3-yl}-3-fluorophenyl)-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one

Base Information

Chemical Name:(5R)-3-(4-{6-[(5S)-5-(aminomethyl)-4,5-dihydroisoxazol-3-yl]pyridin-3-yl}-3-fluorophenyl)-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one
CAS No.:870893-58-6
Molecular Formula:C₂₁H₂₀FN₇O₃
Molecular Weight:437.433
Hs Code.:

Synonyms:(5R)-3-(4-{6-[(5S)-5-(aminomethyl)-4,5-dihydroisoxazol-3-yl]pyridin-3-yl}-3-fluorophenyl)-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one

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Chemical Property of (5R)-3-(4-{6-[(5S)-5-(aminomethyl)-4,5-dihydroisoxazol-3-yl]pyridin-3-yl}-3-fluorophenyl)-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one

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Technology Process of (5R)-3-(4-{6-[(5S)-5-(aminomethyl)-4,5-dihydroisoxazol-3-yl]pyridin-3-yl}-3-fluorophenyl)-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one

There total 19 articles about (5R)-3-(4-{6-[(5S)-5-(aminomethyl)-4,5-dihydroisoxazol-3-yl]pyridin-3-yl}-3-fluorophenyl)-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl {[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}carbamate

: 870893-58-6
(5R)-3-(4-{6-[(5S)-5-(aminomethyl)-4,5-dihydroisoxazol-3-yl]pyridin-3-yl}-3-fluorophenyl)-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); for 18h;

Reference yield:

: acetic acid (5R)-3-(3-fluoro-4-iodophenyl)-2-oxooxazolidin-5-ylmethyl ester

: 870893-58-6
(5R)-3-(4-{6-[(5S)-5-(aminomethyl)-4,5-dihydroisoxazol-3-yl]pyridin-3-yl}-3-fluorophenyl)-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: methanol; potassium carbonate / dichloromethane / 0.42 h / 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C

3: sodium azide / DMF (N,N-dimethyl-formamide) / 75 °C

4: 1,4-dioxane / 100 °C

5: triethylamine / trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane / 1.5 h / 100 °C

6: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide); water / 1 h / 85 °C

7: hydrogenchloride / 1,4-dioxane; DMF (N,N-dimethyl-formamide) / 18 h

With hydrogenchloride; methanol; sodium azide; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trans-bis(triphenylphosphine)palladium dichloride; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); dichloromethane; water;

Reference yield:

: acetic acid (5R)-3-(3-fluorophenyl)-2-oxooxazolidin-5-ylmethyl ester

: 870893-58-6
(5R)-3-(4-{6-[(5S)-5-(aminomethyl)-4,5-dihydroisoxazol-3-yl]pyridin-3-yl}-3-fluorophenyl)-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: iodine; silver trifluoroacetate / chloroform; acetonitrile / 36.5 h / 20 °C

2: methanol; potassium carbonate / dichloromethane / 0.42 h / 20 °C

3: triethylamine / dichloromethane / 0 - 20 °C

4: sodium azide / DMF (N,N-dimethyl-formamide) / 75 °C

5: 1,4-dioxane / 100 °C

6: triethylamine / trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane / 1.5 h / 100 °C

7: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide); water / 1 h / 85 °C

8: hydrogenchloride / 1,4-dioxane; DMF (N,N-dimethyl-formamide) / 18 h

With hydrogenchloride; methanol; sodium azide; iodine; silver trifluoroacetate; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trans-bis(triphenylphosphine)palladium dichloride; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); dichloromethane; chloroform; water; acetonitrile;