N-(2-(2-((3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl)acetyl)phenyl)-4-methylpent-3-enamide

Base Information

Chemical Name:N-(2-(2-((3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl)acetyl)phenyl)-4-methylpent-3-enamide
CAS No.:1331871-20-5
Molecular Formula:C₂₁H₂₅N₃O₄
Molecular Weight:383.447
Hs Code.:

Synonyms:N-(2-(2-((3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl)acetyl)phenyl)-4-methylpent-3-enamide

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Chemical Property of N-(2-(2-((3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl)acetyl)phenyl)-4-methylpent-3-enamide

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Technology Process of N-(2-(2-((3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl)acetyl)phenyl)-4-methylpent-3-enamide

There total 7 articles about N-(2-(2-((3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl)acetyl)phenyl)-4-methylpent-3-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41199-96-6
4-methyl-3-pentenoic acid chloride

: gallaecimonamide A

: 1331871-20-5
N-(2-(2-((3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl)acetyl)phenyl)-4-methylpent-3-enamide

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.tet.2011.05.112

Reference yield:

: 1331871-16-9
(S)-methyl 1-((S)-2-(((benzyloxy)carbonyl)amino)-4-(2-((tert-butoxycarbonyl)amino)phenyl)-4-oxobutanoyl)pyrrolidine-2-carboxylate

: 1331871-20-5
N-(2-(2-((3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl)acetyl)phenyl)-4-methylpent-3-enamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen; acetic acid / ethanol / 13.5 h / 20 °C / 760.05 Torr

2: trifluoroacetic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

3: pyridine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With pyridine; palladium 10% on activated carbon; hydrogen; acetic acid; trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1016/j.tet.2011.05.112

Reference yield:

: 1331871-18-1
C₂₀H₂₅N₃O₅

: 1331871-20-5
N-(2-(2-((3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl)acetyl)phenyl)-4-methylpent-3-enamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

2: pyridine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With pyridine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.tet.2011.05.112