1,1-dimethylethyl [3-phenyl-2-({[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-thienyl]carbonyl}amino)propyl]carbamate

Base Information

• Chemical Name: 1,1-dimethylethyl [3-phenyl-2-({[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-thienyl]carbonyl}amino)propyl]carbamate
• CAS No.: 943322-48-3
• Molecular Formula: C₂₅H₃₅BN₂O₅S
• Molecular Weight: 486.44

Synonyms:1,1-dimethylethyl [3-phenyl-2-({[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-thienyl]carbonyl}amino)propyl]carbamate

Chemical Property of 1,1-dimethylethyl [3-phenyl-2-({[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-thienyl]carbonyl}amino)propyl]carbamate

Chemical Property:

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Technology Process of 1,1-dimethylethyl [3-phenyl-2-({[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-thienyl]carbonyl}amino)propyl]carbamate

There total 2 articles about 1,1-dimethylethyl [3-phenyl-2-({[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-thienyl]carbonyl}amino)propyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethylethyl (2-{[(5-bromo-2-thienyl)carbonyl]amino}-3-phenylpropyl)carbamate (943322-49-4) + bis(pinacol)diborane (73183-34-3) → 1,1-dimethylethyl [3-phenyl-2-({[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-thienyl]carbonyl}amino)propyl]carbamate (943322-48-3)

Guidance literature:

dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; at 80 ℃; for 18h;

Reference yield:

→ 1,1-dimethylethyl [3-phenyl-2-({[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-thienyl]carbonyl}amino)propyl]carbamate (943322-48-3)

Guidance literature:

Reference yield: 41.0%

4-bromo-1H-pyrrolo[2,3-b]pyridin-3-ylamine (943323-65-7) + 1,1-dimethylethyl [3-phenyl-2-({[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-thienyl]carbonyl}amino)propyl]carbamate (943322-48-3) → 1,1-dimethylethyl [2-({[5-(3-amino-1H-pyrrolo[2,3-b]pyridin-4-yl)-2-thienyl]carbonyl}amino)-3-phenylpropyl]carbamate (943323-67-9)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 80 ℃; for 12h;

upstream raw materials:

1,1-dimethylethyl (2-{[(5-bromo-2-thienyl)carbonyl]amino}-3-phenylpropyl)carbamate

bis(pinacol)diborane

Downstream raw materials:

1,1-dimethylethyl [2-({[5-(3-amino-1H-pyrrolo[2,3-b]pyridin-4-yl)-2-thienyl]carbonyl}amino)-3-phenylpropyl]carbamate

1,1-dimethylethyl [2-({[5-(1-methyl-1H-1,2,4-triazol-5-yl)-2-thienyl]carbonyl}amino)-3-phenylpropyl]carbamate

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