2-(4-chlorophenyl)-2-diazoacetic acid tert-butyl ester

Base Information

Chemical Name:2-(4-chlorophenyl)-2-diazoacetic acid tert-butyl ester
CAS No.:1005415-69-9
Molecular Formula:C₁₂H₁₃ClN₂O₂
Molecular Weight:252.7
Hs Code.:

Synonyms:2-(4-chlorophenyl)-2-diazoacetic acid tert-butyl ester

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Chemical Property of 2-(4-chlorophenyl)-2-diazoacetic acid tert-butyl ester

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Technology Process of 2-(4-chlorophenyl)-2-diazoacetic acid tert-butyl ester

There total 3 articles about 2-(4-chlorophenyl)-2-diazoacetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 33155-59-8
tert-butyl 2-(4-chlorophenyl)acetate

: 1005415-69-9
2-(4-chlorophenyl)-2-diazoacetic acid tert-butyl ester

Guidance literature:: With 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 0 - 20 ℃; Schlenk technique; Inert atmosphere; Darkness;
DOI:10.1002/chem.202000081

Reference yield:

: 1878-66-6
4-chlorophenylacetic Acid

: 1005415-69-9
2-(4-chlorophenyl)-2-diazoacetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid; magnesium sulfate / dichloromethane / 40 °C

2: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile

With sulfuric acid; 4-acetamidobenzenesulfonyl azide; magnesium sulfate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; acetonitrile;
DOI:10.1021/acs.joc.0c01590

Reference yield:

: 52449-43-1
(4-chloro-phenyl)-acetic acid methyl ester

: 1005415-69-9
2-(4-chlorophenyl)-2-diazoacetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 12 h / 0 - 25 °C / Inert atmosphere

2: 4-toluenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 12 h / 25 °C

With 4-toluenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; acetonitrile;
DOI:10.1021/acs.orglett.9b01456