diethyl (S_s,1R,2R)-1-chloro-2-phenyl-2-(p-toluenesulfinamido)ethylphosphonate

Base Information

Chemical Name:diethyl (S_s,1R,2R)-1-chloro-2-phenyl-2-(p-toluenesulfinamido)ethylphosphonate
CAS No.:220586-51-6
Molecular Formula:C₁₉H₂₅ClNO₄PS
Molecular Weight:429.905
Hs Code.:

diethyl (S<sub>s</sub>,1R,2R)-1-chloro-2-phenyl-2-(p-toluenesulfinamido)ethylphosphonate

Synonyms:diethyl (S_s,1R,2R)-1-chloro-2-phenyl-2-(p-toluenesulfinamido)ethylphosphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl (S_s,1R,2R)-1-chloro-2-phenyl-2-(p-toluenesulfinamido)ethylphosphonate

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Technology Process of diethyl (S_s,1R,2R)-1-chloro-2-phenyl-2-(p-toluenesulfinamido)ethylphosphonate

There total 1 articles about diethyl (S_s,1R,2R)-1-chloro-2-phenyl-2-(p-toluenesulfinamido)ethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 3167-63-3
diethyl chloromethylphosphonate

: 350479-90-2
(S,E)-N-benzylidene-4-methylbenzenesulfinamide

: 220586-50-5
diethyl (S_s,1S,2R)-1-chloro-2-phenyl-2-(p-toluenesulfinamido)ethylphosphonate

: 220586-51-6
diethyl (S_s,1R,2R)-1-chloro-2-phenyl-2-(p-toluenesulfinamido)ethylphosphonate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;
DOI:10.1016/S0040-4039(98)02331-4

Reference yield: 75.0%

: 220586-51-6
diethyl (S_s,1R,2R)-1-chloro-2-phenyl-2-(p-toluenesulfinamido)ethylphosphonate

: 220586-53-8
diethyl (S_s,2R,3R)-(+)-N-(p-toluenesulfinyl)-3-phenylaziridine-2-phosphonate

Guidance literature:: With sodium hydride;
DOI:10.1016/S0040-4039(98)02331-4

Reference yield:

: 220586-51-6
diethyl (S_s,1R,2R)-1-chloro-2-phenyl-2-(p-toluenesulfinamido)ethylphosphonate

: 118867-00-8
(R)-(1-Amino-2-phenylethyl)phosphonsaeure-diethylester

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / NaH / tetrahydrofuran; cyclohexane / 1 h / -78 - 20 °C

2: 91 percent / TFA / acetone; H₂O / 0.25 h / 0 °C

3: 83 percent / HCO₂NH₄ / 10 percent Pd/C / methanol / 16 h

With ammonium formate; sodium hydride; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; cyclohexane; water; acetone;
DOI:10.1021/jo020707z