C₂₂H₂₀F₁₂NP

Base Information

• Chemical Name: C₂₂H₂₀F₁₂NP
• CAS No.: 1448856-85-6
• Molecular Formula: C₂₂H₂₀F₁₂NP
• Molecular Weight: 557.362
• Mol file: 1448856-85-6.mol

Synonyms:C₂₂H₂₀F₁₂NP

Chemical Property of C₂₂H₂₀F₁₂NP

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₀F₁₂NP

There total 1 articles about C₂₂H₂₀F₁₂NP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N,N-diisopropylphosphoramide dichloride (921-26-6) + 3,5-bis(trifluoromethyl)phenylmagnesium bromide (112981-69-8) → C22H20F12NP (1448856-85-6)

Guidance literature:

In tetrahydrofuran; for 72h; Reflux;

DOI:10.1002/anie.201206297

Reference yield: 94.0%

C22H20F12NP (1448856-85-6) → bis(3,5-bis(trifluoromethyl)phenyl)phosphine (166172-69-6)

Guidance literature:

C₂₂H₂₀F₁₂NP; With hydrogenchloride; In diethyl ether; at 0 - 20 ℃; for 1h;

With lithium aluminium tetrahydride; In diethyl ether; at -78 ℃; for 2h; Reflux;

DOI:10.1002/anie.201206297

Reference yield:

C22H20F12NP (1448856-85-6) → C36H19F12O2P

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride / diethyl ether / 1 h / 0 - 20 °C

1.2: 2 h / -78 °C / Reflux

2.1: copper(l) iodide; N,N`-dimethylethylenediamine; caesium carbonate / toluene / 48 h / Reflux

3.1: hydrogenchloride; water / methanol / 16 h / Reflux

With hydrogenchloride; copper(l) iodide; water; caesium carbonate; N,N`-dimethylethylenediamine; In methanol; diethyl ether; toluene;

DOI:10.1002/anie.201206297

upstream raw materials:

N,N-diisopropylphosphoramide dichloride

3,5-bis(trifluoromethyl)phenylmagnesium bromide

Downstream raw materials:

bis(3,5-bis(trifluoromethyl)phenyl)phosphine