(2S)-8-[(1R)-1-(2-hydroxyphenyl)-3-phenylpropyl]-5,7,3',4'-tetramethoxyflavan

Base Information

Chemical Name:(2S)-8-[(1R)-1-(2-hydroxyphenyl)-3-phenylpropyl]-5,7,3',4'-tetramethoxyflavan
CAS No.:299412-48-9
Molecular Formula:C₃₄H₃₆O₆
Molecular Weight:540.656
Hs Code.:

Synonyms:(2S)-8-[(1R)-1-(2-hydroxyphenyl)-3-phenylpropyl]-5,7,3',4'-tetramethoxyflavan

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Chemical Property of (2S)-8-[(1R)-1-(2-hydroxyphenyl)-3-phenylpropyl]-5,7,3',4'-tetramethoxyflavan

Chemical Property:

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Technology Process of (2S)-8-[(1R)-1-(2-hydroxyphenyl)-3-phenylpropyl]-5,7,3',4'-tetramethoxyflavan

There total 1 articles about (2S)-8-[(1R)-1-(2-hydroxyphenyl)-3-phenylpropyl]-5,7,3',4'-tetramethoxyflavan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 299412-46-7
(2S)-5,7,3',4'-tetrakis[(trifluoromethanesulfonyl)oxy]flavan-4β,8-[(2S)-5,7,3',4'-tetramethoxyflavan]

: (2S)-flavan-4β,8-[(2S)-5,7,3',4'-tetramethoxyflavan]

: 299412-48-9
(2S)-8-[(1R)-1-(2-hydroxyphenyl)-3-phenylpropyl]-5,7,3',4'-tetramethoxyflavan

: (R)-3,5-dimethoxy-2-[3-(3,4-dimethoxyphenyl)propyl]-6-[1-(2-hydroxyphenyl)-3-phenylpropyl]phenol

Guidance literature:: With hydrogen; triethylamine; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 9h; under 750.075 Torr;
DOI:10.1021/jo000485+

Reference yield: 94.0%

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 299412-48-9
(2S)-8-[(1R)-1-(2-hydroxyphenyl)-3-phenylpropyl]-5,7,3',4'-tetramethoxyflavan

: 299412-50-3
Trifluoro-methanesulfonic acid 2-{(R)-1-[(S)-2-(3,4-dimethoxy-phenyl)-5,7-dimethoxy-chroman-8-yl]-3-phenyl-propyl}-phenyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at -40 - 20 ℃; for 2h;
DOI:10.1021/jo000485+

Reference yield:

: 299412-48-9
(2S)-8-[(1R)-1-(2-hydroxyphenyl)-3-phenylpropyl]-5,7,3',4'-tetramethoxyflavan

: 1083-30-3
dihydrochalcone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 94 percent / DBU / dimethylformamide / 2 h / -40 - 20 °C

2.1: 94 percent / H₂; Et₃N / Pd/C / ethyl acetate / 3 h / 20 °C / 750.08 Torr

3.1: NaIO₄; RuCl₃*xH₂O / CCl₄; acetonitrile; H₂O / 2 h / 20 °C

3.2: tetrahydrofuran; methanol / 65 h / 20 °C

With ruthenium trichloride; sodium periodate; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium on activated charcoal; In tetrachloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 1.1: Substitution / 2.1: Hydrogenolysis / 3.1: Oxidation / 3.2: Alkylation;
DOI:10.1021/jo000485+