([5-(4-hydroxyphenyl)-3-(4-fluorophenyl)-1H-pyrrol-2-yl]-[5-(4-hydroxyphenyl)-3-(4-fluorophenyl)pyrrol-2-ylidene]amine)BF₂

Base Information

• Chemical Name: ([5-(4-hydroxyphenyl)-3-(4-fluorophenyl)-1H-pyrrol-2-yl]-[5-(4-hydroxyphenyl)-3-(4-fluorophenyl)pyrrol-2-ylidene]amine)BF₂
• CAS No.: 1332457-87-0
• Molecular Formula: C₃₂H₂₀BF₄N₃O₂
• Molecular Weight: 565.334
• Mol file: 1332457-87-0.mol

Synonyms:([5-(4-hydroxyphenyl)-3-(4-fluorophenyl)-1H-pyrrol-2-yl]-[5-(4-hydroxyphenyl)-3-(4-fluorophenyl)pyrrol-2-ylidene]amine)BF₂

Chemical Property of ([5-(4-hydroxyphenyl)-3-(4-fluorophenyl)-1H-pyrrol-2-yl]-[5-(4-hydroxyphenyl)-3-(4-fluorophenyl)pyrrol-2-ylidene]amine)BF₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ([5-(4-hydroxyphenyl)-3-(4-fluorophenyl)-1H-pyrrol-2-yl]-[5-(4-hydroxyphenyl)-3-(4-fluorophenyl)pyrrol-2-ylidene]amine)BF₂

There total 6 articles about ([5-(4-hydroxyphenyl)-3-(4-fluorophenyl)-1H-pyrrol-2-yl]-[5-(4-hydroxyphenyl)-3-(4-fluorophenyl)pyrrol-2-ylidene]amine)BF₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

[5-(4-hydroxyphenyl)-3-(4-fluorophenyl)-1H-pyrrol-2-yl]-[5-(4-hydroxyphenyl)-3-(4-fluorophenyl) pyrrol-2-ylidene]amine (1332391-01-1) → ([5-(4-hydroxyphenyl)-3-(4-fluorophenyl)-1H-pyrrol-2-yl]-[5-(4-hydroxyphenyl)-3-(4-fluorophenyl)pyrrol-2-ylidene]amine)BF2 (1332457-87-0)

Guidance literature:

With boron trifluoride diethyl etherate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jp205236n

Reference yield: 48.0%

[5-(4-hydroxyphenyl)-3-(4-fluorophenyl)-1H-pyrrol-2-yl]-[5-(4-hydroxyphenyl)-3-(4-fluorophenyl) pyrrol-2-ylidene]amine (1332391-01-1) + trifluoroborane diethyl ether (109-63-7) → ([5-(4-hydroxyphenyl)-3-(4-fluorophenyl)-1H-pyrrol-2-yl]-[5-(4-hydroxyphenyl)-3-(4-fluorophenyl)pyrrol-2-ylidene]amine)BF2 (1332457-87-0)

Guidance literature:

With diisopropylethylamine; In dichloromethane; soln. stirred at room temp. under N2 for 24 h; washed (H2O), organic layer septd., dried (Na2SO4), evapd. to dryness, purified (column chromy., silica gel, CH2Cl2/ethyl acetate 9:1);

DOI:10.1021/jp205236n

Reference yield:

4-fluorobenzaldehyde (459-57-4) → ([5-(4-hydroxyphenyl)-3-(4-fluorophenyl)-1H-pyrrol-2-yl]-[5-(4-hydroxyphenyl)-3-(4-fluorophenyl)pyrrol-2-ylidene]amine)BF2 (1332457-87-0)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium hydroxide / ethanol; water / 24 h / 20 °C

2: diethylamine / ethanol / 24 h / Reflux

3: ammonium acetate / ethanol / 24 h / Reflux

4: boron trifluoride diethyl etherate; N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

With boron trifluoride diethyl etherate; ammonium acetate; diethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In ethanol; dichloromethane; water;

DOI:10.1021/jp205236n

upstream raw materials:

1-(4-hydroxyphenyl)-4-nitro-3-(4-fluorophenyl)butan-1-one

[5-(4-hydroxyphenyl)-3-(4-fluorophenyl)-1H-pyrrol-2-yl]-[5-(4-hydroxyphenyl)-3-(4-fluorophenyl) pyrrol-2-ylidene]amine

4-fluorobenzaldehyde

4-Hydroxyacetophenone

Downstream raw materials:

N(C₄NH(C₆H₄OH)(C₆H₄F))(C₄NH(C₆H₄F)(C₆H₄OC(O)C₆H₄C₅H₄Fe(C₅H₅)))BF₂