Trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-pyrimidin-2-yl ester

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Chemical Name:Trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-pyrimidin-2-yl ester
CAS No.:1334686-04-2
Molecular Formula:C₂₈H₃₄F₃N₃O₉S₂
Molecular Weight:677.72
Hs Code.:

Synonyms:Trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-pyrimidin-2-yl ester

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Chemical Property of Trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-pyrimidin-2-yl ester

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Technology Process of Trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-pyrimidin-2-yl ester

There total 2 articles about Trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-pyrimidin-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1334686-03-1
N-[6-(2-tert-Butoxyethoxy)-2-hydroxy-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-4-tert-butylbenzenesulfonamide

: 1334686-04-2
Trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-pyrimidin-2-yl ester

Guidance literature:: With pyridine; at -30 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1334686-10-0
C₂₈H₃₇N₃O₈S₂

: 1334686-04-2
Trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-pyrimidin-2-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / 1,4-dioxane / 1 h / 100 °C

1.2: 0 °C / pH 3 - 4

2.1: pyridine / 1 h / -30 °C / Inert atmosphere

With pyridine; sodium hydroxide; In 1,4-dioxane;

Reference yield: 86.0%

: 1334686-04-2
Trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-pyrimidin-2-yl ester

: 1334686-05-3
trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)pyrimidin-2-yl ester

Guidance literature:: Trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-pyrimidin-2-yl ester; With formic acid; at 85 ℃; for 1.5h;

With potassium carbonate; In methanol; at 0 ℃; for 1h;