trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)pyrimidin-2-yl ester

Base Information

Chemical Name:trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)pyrimidin-2-yl ester
CAS No.:1334686-05-3
Molecular Formula:C₂₄H₂₆F₃N₃O₉S₂
Molecular Weight:621.612
Hs Code.:

Synonyms:trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)pyrimidin-2-yl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)pyrimidin-2-yl ester

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Purity/Quality:: 98% HPLC ^*data from raw suppliers

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Technology Process of trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)pyrimidin-2-yl ester

There total 4 articles about trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)pyrimidin-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1334686-04-2
Trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-pyrimidin-2-yl ester

: 1334686-05-3
trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)pyrimidin-2-yl ester

Guidance literature:: Trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-pyrimidin-2-yl ester; With formic acid; at 85 ℃; for 1.5h;

With potassium carbonate; In methanol; at 0 ℃; for 1h;

Reference yield: 80.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1334686-06-4
4-tert-Butyl-N-[2-hydroxy-6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-benzenesulfonamide

: 1334686-05-3
trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)pyrimidin-2-yl ester

Guidance literature:: With pyridine; at -30 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1334686-10-0
C₂₈H₃₇N₃O₈S₂

: 1334686-05-3
trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)pyrimidin-2-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / 1,4-dioxane / 1 h / 100 °C

1.2: 0 °C / pH 3 - 4

2.1: pyridine / 1 h / -30 °C / Inert atmosphere

3.1: formic acid / 1.5 h / 85 °C

3.2: 1 h / 0 °C

With pyridine; formic acid; sodium hydroxide; In 1,4-dioxane;