(S)-4-(p-methoxybenzyloxycarbonylaminomethyl)-3-(2,2,2-trichloroethoxycarbonyl)-5-oxazolidinone

Base Information

• Chemical Name: (S)-4-(p-methoxybenzyloxycarbonylaminomethyl)-3-(2,2,2-trichloroethoxycarbonyl)-5-oxazolidinone
• CAS No.: 81659-74-7
• Molecular Formula: C₁₆H₁₇Cl₃N₂O₇
• Molecular Weight: 455.679
• Mol file: 81659-74-7.mol

Synonyms:(S)-4-(p-methoxybenzyloxycarbonylaminomethyl)-3-(2,2,2-trichloroethoxycarbonyl)-5-oxazolidinone

Chemical Property of (S)-4-(p-methoxybenzyloxycarbonylaminomethyl)-3-(2,2,2-trichloroethoxycarbonyl)-5-oxazolidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-(p-methoxybenzyloxycarbonylaminomethyl)-3-(2,2,2-trichloroethoxycarbonyl)-5-oxazolidinone

There total 2 articles about (S)-4-(p-methoxybenzyloxycarbonylaminomethyl)-3-(2,2,2-trichloroethoxycarbonyl)-5-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-3-(2,2,2-trichloroethoxycarbonyl)-5-oxo-4-oxazolidineacetic acid (81659-73-6) → (S)-4-(p-methoxybenzyloxycarbonylaminomethyl)-3-(2,2,2-trichloroethoxycarbonyl)-5-oxazolidinone (81659-74-7)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenyl diphosphorazidate, Et₃N / benzene / 15 h

2: benzene / 3 h / Heating

With diphenyl diphosphorazidate; triethylamine; In benzene;

DOI:10.1246/bcsj.55.633

Reference yield:

4-Methoxybenzyl alcohol (105-13-5) + (S)-4-Azidocarbonylmethyl-5-oxo-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester → (S)-4-(p-methoxybenzyloxycarbonylaminomethyl)-3-(2,2,2-trichloroethoxycarbonyl)-5-oxazolidinone (81659-74-7)

Guidance literature:

In benzene; for 3h; Yield given; Heating;

DOI:10.1246/bcsj.55.633

Reference yield: 98.0%

(S)-4-(p-methoxybenzyloxycarbonylaminomethyl)-3-(2,2,2-trichloroethoxycarbonyl)-5-oxazolidinone (81659-74-7) → N3-(p-methoxybenzyloxycarbonyl)-N2-(2,2,2-trichloroethoxycarbonyl)-L-2,3-diaminopropanoic acid (81659-76-9)

Guidance literature:

With sodium hydroxide; In water; acetone; at 0 - 5 ℃; for 2h;

DOI:10.1246/bcsj.55.633

upstream raw materials:

4-Methoxybenzyl alcohol

(S)-3-(2,2,2-trichloroethoxycarbonyl)-5-oxo-4-oxazolidineacetic acid

Downstream raw materials:

N³-(p-methoxybenzyloxycarbonyl)-N²-(2,2,2-trichloroethoxycarbonyl)-L-2,3-diaminopropanoic acid