tert-butyl 3-methoxybenzyl((2R,3S)-4-(3,5-difluorophenyl)-2-hydroxy-3-(3-(1-hydroxyethyl)-5-(N-methylmethan-2-ylsulfonamido)benzamido)butyl)carbamate

Base Information

• Chemical Name: tert-butyl 3-methoxybenzyl((2R,3S)-4-(3,5-difluorophenyl)-2-hydroxy-3-(3-(1-hydroxyethyl)-5-(N-methylmethan-2-ylsulfonamido)benzamido)butyl)carbamate
• CAS No.: 924650-21-5
• Molecular Formula: C₃₄H₄₃F₂N₃O₈S
• Molecular Weight: 691.794

Synonyms:tert-butyl 3-methoxybenzyl((2R,3S)-4-(3,5-difluorophenyl)-2-hydroxy-3-(3-(1-hydroxyethyl)-5-(N-methylmethan-2-ylsulfonamido)benzamido)butyl)carbamate

Chemical Property of tert-butyl 3-methoxybenzyl((2R,3S)-4-(3,5-difluorophenyl)-2-hydroxy-3-(3-(1-hydroxyethyl)-5-(N-methylmethan-2-ylsulfonamido)benzamido)butyl)carbamate

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Technology Process of tert-butyl 3-methoxybenzyl((2R,3S)-4-(3,5-difluorophenyl)-2-hydroxy-3-(3-(1-hydroxyethyl)-5-(N-methylmethan-2-ylsulfonamido)benzamido)butyl)carbamate

There total 2 articles about tert-butyl 3-methoxybenzyl((2R,3S)-4-(3,5-difluorophenyl)-2-hydroxy-3-(3-(1-hydroxyethyl)-5-(N-methylmethan-2-ylsulfonamido)benzamido)butyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-methoxybenzyl((2R,3S)-3-(3-acetyl-5-(N-methylmethan-2-ylsulfonamido)benzamido)-4-(3,5-difluorophenyl)-2-hydroxybutyl)carbamate (924650-20-4) → tert-butyl 3-methoxybenzyl((2R,3S)-4-(3,5-difluorophenyl)-2-hydroxy-3-(3-(1-hydroxyethyl)-5-(N-methylmethan-2-ylsulfonamido)benzamido)butyl)carbamate (924650-21-5)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 2h;

Reference yield:

tert-butyl 3-methoxybenzyl((2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl)-carbamate (924650-42-0) + C11H15NO5S → tert-butyl 3-methoxybenzyl((2R,3S)-4-(3,5-difluorophenyl)-2-hydroxy-3-(3-(1-hydroxyethyl)-5-(N-methylmethan-2-ylsulfonamido)benzamido)butyl)carbamate (924650-21-5)

Guidance literature:

With triethylamine; HATU; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2009.03.144

Reference yield:

tert-butyl 3-methoxybenzyl((2R,3S)-4-(3,5-difluorophenyl)-2-hydroxy-3-(3-(1-hydroxyethyl)-5-(N-methylmethan-2-ylsulfonamido)benzamido)butyl)carbamate (924650-21-5) → C29H35F2N3O6S

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2009.03.144

upstream raw materials:

tert-butyl 3-methoxybenzyl((2R,3S)-3-(3-acetyl-5-(N-methylmethan-2-ylsulfonamido)benzamido)-4-(3,5-difluorophenyl)-2-hydroxybutyl)carbamate

tert-butyl 3-methoxybenzyl((2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl)-carbamate

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