4-(4-tert-butoxycarbonylmethoxycarbonyl-butyl)-2-oxo-hexahydro-thieno[3,4-d]imidazole-1-carboxylic acid 4-(tert-butyl-dimethyl-silanyloxy)-phenyl ester

Base Information

Chemical Name:4-(4-tert-butoxycarbonylmethoxycarbonyl-butyl)-2-oxo-hexahydro-thieno[3,4-d]imidazole-1-carboxylic acid 4-(tert-butyl-dimethyl-silanyloxy)-phenyl ester
CAS No.:817602-45-2
Molecular Formula:C₂₉H₄₄N₂O₈SSi
Molecular Weight:608.828
Hs Code.:

4-(4-<i>tert</i>-butoxycarbonylmethoxycarbonyl-butyl)-2-oxo-hexahydro-thieno[3,4-<i>d</i>]imidazole-1-carboxylic acid 4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-phenyl ester

Synonyms:4-(4-tert-butoxycarbonylmethoxycarbonyl-butyl)-2-oxo-hexahydro-thieno[3,4-d]imidazole-1-carboxylic acid 4-(tert-butyl-dimethyl-silanyloxy)-phenyl ester

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Chemical Property of 4-(4-tert-butoxycarbonylmethoxycarbonyl-butyl)-2-oxo-hexahydro-thieno[3,4-d]imidazole-1-carboxylic acid 4-(tert-butyl-dimethyl-silanyloxy)-phenyl ester

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Technology Process of 4-(4-tert-butoxycarbonylmethoxycarbonyl-butyl)-2-oxo-hexahydro-thieno[3,4-d]imidazole-1-carboxylic acid 4-(tert-butyl-dimethyl-silanyloxy)-phenyl ester

There total 4 articles about 4-(4-tert-butoxycarbonylmethoxycarbonyl-butyl)-2-oxo-hexahydro-thieno[3,4-d]imidazole-1-carboxylic acid 4-(tert-butyl-dimethyl-silanyloxy)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 817602-44-1
4-(tert-butyldimethylsilyloxy)phenoxycarbonyl chloride

: 817602-43-0
5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid tert-butoxycarbonylmethyl ester

: 817602-45-2
4-(4-tert-butoxycarbonylmethoxycarbonyl-butyl)-2-oxo-hexahydro-thieno[3,4-d]imidazole-1-carboxylic acid 4-(tert-butyl-dimethyl-silanyloxy)-phenyl ester

Guidance literature:: 5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid tert-butoxycarbonylmethyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -10 ℃; for 0.0833333h;

4-(tert-butyldimethylsilyloxy)phenoxycarbonyl chloride; In tetrahydrofuran; for 1h;
DOI:10.1021/ja0459330

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 817602-45-2
4-(4-tert-butoxycarbonylmethoxycarbonyl-butyl)-2-oxo-hexahydro-thieno[3,4-d]imidazole-1-carboxylic acid 4-(tert-butyl-dimethyl-silanyloxy)-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: K₂CO₃ / dimethylsulfoxide / 5 h / 20 °C

2.1: LiHMDS / tetrahydrofuran / 0.08 h / -10 °C

2.2: tetrahydrofuran / 1 h

With potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1021/ja0459330

Reference yield:

: 108534-47-0
4-(tert-butyldimethylsilyloxy)phenol

: 817602-45-2
4-(4-tert-butoxycarbonylmethoxycarbonyl-butyl)-2-oxo-hexahydro-thieno[3,4-d]imidazole-1-carboxylic acid 4-(tert-butyl-dimethyl-silanyloxy)-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / toluene; diethyl ether / 2 h / 0 °C

2.1: LiHMDS / tetrahydrofuran / 0.08 h / -10 °C

2.2: tetrahydrofuran / 1 h

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1021/ja0459330