4-(tert-butyldimethylsilyloxy)phenoxycarbonyl chloride

Base Information

Chemical Name:4-(tert-butyldimethylsilyloxy)phenoxycarbonyl chloride
CAS No.:817602-44-1
Molecular Formula:C₁₃H₁₉ClO₃Si
Molecular Weight:286.831
Hs Code.:

Synonyms:4-(tert-butyldimethylsilyloxy)phenoxycarbonyl chloride

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Chemical Property of 4-(tert-butyldimethylsilyloxy)phenoxycarbonyl chloride

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Technology Process of 4-(tert-butyldimethylsilyloxy)phenoxycarbonyl chloride

There total 1 articles about 4-(tert-butyldimethylsilyloxy)phenoxycarbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-44-5
phosgene

: 108534-47-0
4-(tert-butyldimethylsilyloxy)phenol

: 817602-44-1
4-(tert-butyldimethylsilyloxy)phenoxycarbonyl chloride

Guidance literature:: With triethylamine; In diethyl ether; toluene; at 0 ℃; for 2h;
DOI:10.1021/ja0459330

Reference yield:

: 817602-44-1
4-(tert-butyldimethylsilyloxy)phenoxycarbonyl chloride

: 817602-43-0
5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid tert-butoxycarbonylmethyl ester

: 817602-45-2
4-(4-tert-butoxycarbonylmethoxycarbonyl-butyl)-2-oxo-hexahydro-thieno[3,4-d]imidazole-1-carboxylic acid 4-(tert-butyl-dimethyl-silanyloxy)-phenyl ester

Guidance literature:: 5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid tert-butoxycarbonylmethyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -10 ℃; for 0.0833333h;

4-(tert-butyldimethylsilyloxy)phenoxycarbonyl chloride; In tetrahydrofuran; for 1h;
DOI:10.1021/ja0459330

Reference yield:

: 817602-44-1
4-(tert-butyldimethylsilyloxy)phenoxycarbonyl chloride

: (3aS,4S,6aR)-4-[4-(2-{2-[2-((S)-5-[1,2]Dithiolan-3-yl-pentanoyloxy)-ethoxy]-ethoxy}-ethoxycarbonylmethoxycarbonyl)-butyl]-2-oxo-hexahydro-thieno[3,4-d]imidazole-1-carboxylic acid 4-(tert-butyl-dimethyl-silanyloxy)-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: LiHMDS / tetrahydrofuran / 0.08 h / -10 °C

1.2: tetrahydrofuran / 1 h

2.1: 100 percent / trifluoroacetic acid / CHCl₃ / 15 h / 20 °C

3.1: 64 percent / DCC; DMAP / CHCl₃ / 24 h / 20 °C

With dmap; dicyclohexyl-carbodiimide; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; chloroform;
DOI:10.1021/ja0459330