2'-O-(triisopropylsilyl)-7-O-(triethylsilyl)-N-debenzoyl-N-methoxycarbonylpaclitaxel

Base Information

Chemical Name:2'-O-(triisopropylsilyl)-7-O-(triethylsilyl)-N-debenzoyl-N-methoxycarbonylpaclitaxel
CAS No.:1167414-82-5
Molecular Formula:C₅₇H₈₃NO₁₅Si₂
Molecular Weight:1078.45
Hs Code.:

Synonyms:2'-O-(triisopropylsilyl)-7-O-(triethylsilyl)-N-debenzoyl-N-methoxycarbonylpaclitaxel

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2'-O-(triisopropylsilyl)-7-O-(triethylsilyl)-N-debenzoyl-N-methoxycarbonylpaclitaxel

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Technology Process of 2'-O-(triisopropylsilyl)-7-O-(triethylsilyl)-N-debenzoyl-N-methoxycarbonylpaclitaxel

There total 1 articles about 2'-O-(triisopropylsilyl)-7-O-(triethylsilyl)-N-debenzoyl-N-methoxycarbonylpaclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 181116-66-5
(3R,4S)-1-methoxycarbonyl-3-triisopropylsilyloxy-4-phenyl-azetidin-2-one

: 115437-21-3
7-(triethylsilyl)baccatin III

: 1167414-82-5
2'-O-(triisopropylsilyl)-7-O-(triethylsilyl)-N-debenzoyl-N-methoxycarbonylpaclitaxel

Guidance literature:: 7-(triethylsilyl)baccatin III; With lithium hexamethyldisilazane; In tetrahydrofuran; at -42 ℃; for 0.0833333h;

(3R,4S)-1-methoxycarbonyl-3-triisopropylsilyloxy-4-phenyl-azetidin-2-one; In tetrahydrofuran; at -42 ℃; for 3h;
DOI:10.1016/j.bmcl.2009.03.063