Chemical Property of Levophta
Chemical Property:
- Vapor Pressure:8.77E-16mmHg at 25°C
- Boiling Point:611oC at 760 mmHg
- Flash Point:323.3oC
- PSA：64.33000
- LogP:5.63398
- Storage Temp.:2-8°C
- Solubility.:DMSO: ~10 mg/mL, soluble
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:4
- Exact Mass:456.1979841
- Heavy Atom Count:32
- Complexity:681
- Purity/Quality:
-
99%, *data from raw suppliers
(3S,4R)-CabastineHydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
Moderately toxic by ingestion.
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1CN(CCC1(C2=CC=CC=C2)C(=O)O)C3CCC(CC3)(C#N)C4=CC=C(C=C4)F.Cl
- Isomeric SMILES:C[C@H]1CN(CC[C@]1(C2=CC=CC=C2)C(=O)O)C3CCC(CC3)(C#N)C4=CC=C(C=C4)F.Cl
- Recent EU Clinical Trials:A randomised, double-blind, placebo-controlled, 3 way, incomplete block cross over study in subjects with allergic rhinitis to assess the effect of once daily single and repeat doses of intranasal Fluticasone furoate/Levocabastine fixed dose combination (FDC) relative to Levocabastine and Fluticasone furoate alone on the onset and magnitude of symptoms of rhinitis in an allergen challenge chamber
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Description
Levocabastine hydrochloride is a new, highly potent and specific histamine HI-receptor
antagonist without anticholinergic or antiserotonergic side effects. It is reported to
have both a fast onset and long duration of action. Indications are the treatment of
allergic conjunctivitis and allergic rhinitis.
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Uses
A histamine H1 receptor antagonist used in allergic conjunctivitis.
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Therapeutic Function
Antihistaminic
