(Z)-methyl 4-(1-(4-fluorobenzyl)-1H-pyrrol-2-yl)-2-hydroxy-4-oxobut-2-enoate

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Chemical Name:(Z)-methyl 4-(1-(4-fluorobenzyl)-1H-pyrrol-2-yl)-2-hydroxy-4-oxobut-2-enoate
CAS No.:905729-22-8
Molecular Formula:C₁₆H₁₄FNO₄
Molecular Weight:303.29
Hs Code.:

Synonyms:(Z)-methyl 4-(1-(4-fluorobenzyl)-1H-pyrrol-2-yl)-2-hydroxy-4-oxobut-2-enoate

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Chemical Property of (Z)-methyl 4-(1-(4-fluorobenzyl)-1H-pyrrol-2-yl)-2-hydroxy-4-oxobut-2-enoate

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Technology Process of (Z)-methyl 4-(1-(4-fluorobenzyl)-1H-pyrrol-2-yl)-2-hydroxy-4-oxobut-2-enoate

There total 3 articles about (Z)-methyl 4-(1-(4-fluorobenzyl)-1H-pyrrol-2-yl)-2-hydroxy-4-oxobut-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 251924-61-5
1-[1-(4-fluorobenzyl)-1H-pyrrol-2-yl]ethanone

: 553-90-2
Dimethyl oxalate

: 905729-22-8
(Z)-methyl 4-(1-(4-fluorobenzyl)-1H-pyrrol-2-yl)-2-hydroxy-4-oxobut-2-enoate

Guidance literature:: 1-[1-(4-fluorobenzyl)-1H-pyrrol-2-yl]ethanone; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.166667h;

Dimethyl oxalate; In tetrahydrofuran; at 0 ℃; for 0.5h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 1192-62-7,80145-44-4
1-(2-furyl)-1-ethanone

: 905729-22-8
(Z)-methyl 4-(1-(4-fluorobenzyl)-1H-pyrrol-2-yl)-2-hydroxy-4-oxobut-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 75 percent / aq. NH₃ / ethanol / 12 h / 150 °C

2.1: KOH / dimethylsulfoxide / 0.75 h / 20 °C

2.2: 94 percent / dimethylsulfoxide / 0.75 h / 20 °C

3.1: 68 percent / NaH / dimethylformamide / 4.5 h / 20 - 50 °C

With potassium hydroxide; ammonium hydroxide; sodium hydride; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; 3.1: Claisen condensation;
DOI:10.1021/jm060193m

Reference yield:

: 1072-83-9
2-Acetylpyrrole

: 905729-22-8
(Z)-methyl 4-(1-(4-fluorobenzyl)-1H-pyrrol-2-yl)-2-hydroxy-4-oxobut-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: KOH / dimethylsulfoxide / 0.75 h / 20 °C

1.2: 94 percent / dimethylsulfoxide / 0.75 h / 20 °C

2.1: 68 percent / NaH / dimethylformamide / 4.5 h / 20 - 50 °C

With potassium hydroxide; sodium hydride; In dimethyl sulfoxide; N,N-dimethyl-formamide; 2.1: Claisen condensation;
DOI:10.1021/jm060193m