N'-(5-nitropyridin-2-yl)acetohydrazide

Base Information

• Chemical Name: N'-(5-nitropyridin-2-yl)acetohydrazide
• CAS No.: 31053-00-6
• Molecular Formula: C₇H₈N₄O₃
• Molecular Weight: 196.166
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID40401456
• NSC Number: 110285
• Wikidata: Q82204570
• Mol file: 31053-00-6.mol

Synonyms:31053-00-6;N'-(5-nitropyridin-2-yl)acetohydrazide;NSC110285;SCHEMBL10881152;DTXSID40401456;XQRAZEZSFSYOBV-UHFFFAOYSA-N;AKOS016510379;N'-(5-Nitro-2-pyridyl)acethydrazide;NSC-110285

Chemical Property of N'-(5-nitropyridin-2-yl)acetohydrazide

Chemical Property:

• Boiling Point: 324.8oC at 760 mmHg
• Flash Point: 150.2oC
• PSA: 103.07000
• Density: 1.438g/cm3
• LogP: 0.78880
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 196.05964013
• Heavy Atom Count: 14
• Complexity: 228

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NNC1=NC=C(C=C1)[N+](=O)[O-]

Technology Process of N'-(5-nitropyridin-2-yl)acetohydrazide

There total 4 articles about N'-(5-nitropyridin-2-yl)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-hydrazino-5-nitropyridine (6343-98-2) + acetyl chloride (75-36-5) → 2-Acetylhydrazid-5-nitropyridin (31053-00-6)

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1016/j.tetlet.2016.01.094

Reference yield:

2-chloro-5-nitropyridine (4548-45-2) → 2-Acetylhydrazid-5-nitropyridin (31053-00-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / isopropyl alcohol / 20 °C / Cooling with ice

2: pyridine / N,N-dimethyl-formamide / 0 - 20 °C

With pyridine; hydrazine hydrate; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.tetlet.2016.01.094

Reference yield:

2-hydrazino-5-nitropyridine (6343-98-2) → 2-Acetylhydrazid-5-nitropyridin (31053-00-6)

Guidance literature:

With acetic acid;

upstream raw materials:

2-hydrazino-5-nitropyridine

2-chloro-5-nitropyridine

acetyl chloride