(R)-tri-tert-butyl 2,2',2-(10-(3-(benzyloxy)-2-(((benzyloxy)carbonyl)amino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Base Information

Chemical Name:(R)-tri-tert-butyl 2,2',2-(10-(3-(benzyloxy)-2-(((benzyloxy)carbonyl)amino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate
CAS No.:1414168-27-6
Molecular Formula:C₄₄H₆₇N₅O₁₀
Molecular Weight:826.043
Hs Code.:

Synonyms:(R)-tri-tert-butyl 2,2',2-(10-(3-(benzyloxy)-2-(((benzyloxy)carbonyl)amino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

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Chemical Property of (R)-tri-tert-butyl 2,2',2-(10-(3-(benzyloxy)-2-(((benzyloxy)carbonyl)amino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

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Technology Process of (R)-tri-tert-butyl 2,2',2-(10-(3-(benzyloxy)-2-(((benzyloxy)carbonyl)amino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

There total 4 articles about (R)-tri-tert-butyl 2,2',2-(10-(3-(benzyloxy)-2-(((benzyloxy)carbonyl)amino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1414168-19-6
benzyl 2-(((benzyloxy)carbonyl)amino)-3-(1,4,7,10-tetraazacyclododecan-1-yl)propanoate

: 1414168-27-6
(R)-tri-tert-butyl 2,2',2-(10-(3-(benzyloxy)-2-(((benzyloxy)carbonyl)amino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 16h;

Reference yield:

: 53933-06-5
L-(benzyloxycarbonyl)amino serine benzyl ester

: 1414168-27-6
(R)-tri-tert-butyl 2,2',2-(10-(3-(benzyloxy)-2-(((benzyloxy)carbonyl)amino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2: potassium carbonate / acetonitrile / 16 h / 50 °C

3: potassium carbonate / acetonitrile / 16 h / 20 °C

With potassium carbonate; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1021/ja309187m

Reference yield:

: 1414168-11-8
(R)-benzyl 2-(((benzyloxy)carbonyl)amino)-3-((methylsulfonyl)oxy)propanoate

: 1414168-27-6
(R)-tri-tert-butyl 2,2',2-(10-(3-(benzyloxy)-2-(((benzyloxy)carbonyl)amino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 16 h / 50 °C

2: potassium carbonate / acetonitrile / 16 h / 20 °C

With potassium carbonate; In acetonitrile;
DOI:10.1021/ja309187m