benzyl 2-(((benzyloxy)carbonyl)amino)-3-(1,4,7,10-tetraazacyclododecan-1-yl)propanoate

Base Information

Chemical Name:benzyl 2-(((benzyloxy)carbonyl)amino)-3-(1,4,7,10-tetraazacyclododecan-1-yl)propanoate
CAS No.:1414168-19-6
Molecular Formula:C₂₆H₃₇N₅O₄
Molecular Weight:483.611
Hs Code.:

Synonyms:benzyl 2-(((benzyloxy)carbonyl)amino)-3-(1,4,7,10-tetraazacyclododecan-1-yl)propanoate

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Chemical Property of benzyl 2-(((benzyloxy)carbonyl)amino)-3-(1,4,7,10-tetraazacyclododecan-1-yl)propanoate

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Technology Process of benzyl 2-(((benzyloxy)carbonyl)amino)-3-(1,4,7,10-tetraazacyclododecan-1-yl)propanoate

There total 2 articles about benzyl 2-(((benzyloxy)carbonyl)amino)-3-(1,4,7,10-tetraazacyclododecan-1-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1414168-11-8
(R)-benzyl 2-(((benzyloxy)carbonyl)amino)-3-((methylsulfonyl)oxy)propanoate

: 294-90-6
1,4,7,10-tetraazacyclododecan

: 1414168-19-6
benzyl 2-(((benzyloxy)carbonyl)amino)-3-(1,4,7,10-tetraazacyclododecan-1-yl)propanoate

Guidance literature:: With potassium carbonate; In acetonitrile; at 50 ℃; for 16h;
DOI:10.1021/ja309187m

Reference yield:

: 53933-06-5
L-(benzyloxycarbonyl)amino serine benzyl ester

: 1414168-19-6
benzyl 2-(((benzyloxy)carbonyl)amino)-3-(1,4,7,10-tetraazacyclododecan-1-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2: potassium carbonate / acetonitrile / 16 h / 50 °C

With potassium carbonate; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1021/ja309187m

Reference yield: 36.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1414168-19-6
benzyl 2-(((benzyloxy)carbonyl)amino)-3-(1,4,7,10-tetraazacyclododecan-1-yl)propanoate

: 100-39-0
benzyl bromide

: ditert-butyl (R)-2,2′-(4-benzyl-10-(3-(benzyloxy)-2-(((benzyloxy)carbonyl)amino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

: ditert-butyl (R)-2,2′-(7-benzyl-10-(3-(benzyloxy)-2-(((benzyloxy)carbonyl)amino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,4-diyl)diacetate

Guidance literature:: benzyl 2-(((benzyloxy)carbonyl)amino)-3-(1,4,7,10-tetraazacyclododecan-1-yl)propanoate; benzyl bromide; With potassium carbonate; In acetonitrile; at 20 ℃; for 16h;

bromoacetic acid tert-butyl ester; In acetonitrile; at 20 ℃; for 1.5h;
DOI:10.1021/ic503035f