ethyl 6-((3-(trifluoromethoxy)phenyl)carbamoyl)nicotinate

Base Information

• Chemical Name: ethyl 6-((3-(trifluoromethoxy)phenyl)carbamoyl)nicotinate
• CAS No.: 1437125-45-5
• Molecular Formula: C₁₆H₁₃F₃N₂O₄
• Molecular Weight: 354.285
• Mol file: 1437125-45-5.mol

Synonyms:ethyl 6-((3-(trifluoromethoxy)phenyl)carbamoyl)nicotinate

Chemical Property of ethyl 6-((3-(trifluoromethoxy)phenyl)carbamoyl)nicotinate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of ethyl 6-((3-(trifluoromethoxy)phenyl)carbamoyl)nicotinate

There total 3 articles about ethyl 6-((3-(trifluoromethoxy)phenyl)carbamoyl)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

5-ethyl hydro-2,5-pyridinedicarboxylate (17880-34-1) + m-trifluoromethoxyaniline (1535-73-5) → ethyl 6-((3-(trifluoromethoxy)phenyl)carbamoyl)nicotinate (1437125-45-5)

Guidance literature:

With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

ethyl 2,5-pyridinedicarboxylate (5552-44-3) → ethyl 6-((3-(trifluoromethoxy)phenyl)carbamoyl)nicotinate (1437125-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol / 4 h / Reflux

1.2: 0 - 20 °C

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 20 °C

With 1,1'-carbonyldiimidazole; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

Reference yield:

Pyridine-2,5-dicarboxylic acid (100-26-5) → ethyl 6-((3-(trifluoromethoxy)phenyl)carbamoyl)nicotinate (1437125-45-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid / 4 h / Reflux

2.1: sodium hydroxide / ethanol / 4 h / Reflux

2.2: 0 - 20 °C

3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 20 °C

With sulfuric acid; 1,1'-carbonyldiimidazole; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

ethyl 2,5-pyridinedicarboxylate

Pyridine-2,5-dicarboxylic acid

5-ethyl hydro-2,5-pyridinedicarboxylate

m-trifluoromethoxyaniline

Downstream raw materials:

5-(hydroxymethyl)-N-(3-(trifluoromethoxy)phenyl)picolinamide

5-(chloromethyl)-N-(3-(trifluoromethoxy)phenyl)picolinamide