5552-44-3

Basic information

• Product Name: 2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER
• Synonyms: DIETHYL 2,5-PYRIDINEDICARBOXYLATE;2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER;2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER 98+%;Diethyl isocinchomeronate;Isocinchomeronic acid diethyl ester;Pyridine-2,5-dicarboxylic acid diethyl ester;Nsc79261;Diethyl pyridine-2,5-dicarboxylate
• CAS NO: 5552-44-3
• Molecular Formula: C₁₁H₁₃NO₄
• Molecular Weight: 223.23
• Product Categories: Heterocycle-Pyridine series
• Mol File: 5552-44-3.mol

Chemical Properties

• Melting Point: 46 °C
• Boiling Point: 181 °C / 17mmHg
• Flash Point: 154.1°C
• Appearance: /
• Density: 1.165g/cm³
• Vapor Pressure: 5.44E-11mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER(5552-44-3)
• EPA Substance Registry System: 2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER(5552-44-3)

Safety Data

• Hazardous Substances Data: 5552-44-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER is used as an intermediate in the synthesis of various pharmaceutical compounds for its versatile chemical properties and reactivity.
Used in Agrochemical Industry:
2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER is used as a building block in the development of agrochemicals, contributing to the creation of effective crop protection agents.
Used in Organic Synthesis:
2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER is used as a key component in organic synthesis, enabling the formation of a wide range of organic compounds due to its functional groups.
Used in Food and Beverage Industry:
2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER is used as a flavor and fragrance ingredient, adding unique taste and aroma profiles to food and beverage products.
Used in Laboratory and Industrial Settings:
2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER is used with caution as a potential skin irritant, requiring proper handling and safety measures to prevent adverse effects on human skin.

InChI:InChI=1/C21H25N3O5/c1-14-8-10-23(11-9-14)18-6-4-15(12-19(18)24(26)27)21(25)22-17-13-16(28-2)5-7-20(17)29-3/h4-7,12-14H,8-11H2,1-3H3,(H,22,25)

Upstream product

• 16110-09-1 2,5 dichloropyridine 
• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 
• 100-26-5 Pyridine-2,5-dicarboxylic acid 
• 5620-35-9 pyridine-2,5-dicarboxylic acid dichloride 

Downstream Products

• 21514-99-8 2,5-bis[hydroxymethyl]-pyridine 
• 17874-78-1 6-ethoxycarbonylpyridine-3-carboxylic acid 
• 17880-34-1 5-ethyl hydro-2,5-pyridinedicarboxylate 
• 20857-31-2 ethyl 6-formyl-pyridine-3-carboxylate 
• 1437125-80-8 5-(chloromethyl)-N-(4-(trifluoromethoxy)phenyl)picolinamide 
• 1437125-75-1 5-(chloromethyl)-N-(3-(trifluoromethoxy)phenyl)picolinamide 
• 1437125-70-6 C₁₄H₁₀ClF₃N₂O 
• 1437125-65-9 5-(hydroxymethyl)-N-(4-(trifluoromethoxy)phenyl)picolinamide 
• 1437125-60-4 5-(hydroxymethyl)-N-(3-(trifluoromethoxy)phenyl)picolinamide 
• 1437125-55-7 5-(hydroxymethyl)-N-(3-(trifluoromethyl)phenyl)picolinamide 
• 1437125-50-2 ethyl 6-((4-(trifluoromethoxy)phenyl)carbamoyl)nicotinate 
• 1437125-45-5 ethyl 6-((3-(trifluoromethoxy)phenyl)carbamoyl)nicotinate 
• 1437125-40-0 C₁₆H₁₃F₃N₂O₃ 
• 1437121-85-1 5-((9-nitro-5,6-dihydro-2H-imidazo[2,1-b][1,3,6]oxadiazocin-4(3H)-yl)methyl)-N-(4-(trifluoromethoxy)phenyl)picolinamide 

Relevant articles and documents

6-(4-Phenyl-benzyloxy-methyl) guvacine. Synthesis, GABA uptake inhibitor and muscarinic properties

6-(4-Phenyl-benzyloxy-methyl) guvacine was synthesized. Surprisingly the compound was devoid of the γ-aminobutyric acid (GABA) uptake inhibitory activity of its parent compound guvacine, but instead showed affinities for the muscarinic M1 and M2 receptors.

Nuclearity growth towards Ni(ii) cubane in self-assembly with 2-hydroxymethyl pyridine (hmpH) and 5-ethoxycarbonyl-2-hydroxymethyl pyridine (5-ehmpH)

Self-assembly of NiX2 (X = Br or OAc) with 2-hydroxymethyl pyridine (hmpH) and 5-ethoxycarbonyl-2-hydroxymethyl pyridine (5-ehmpH) results in six new Ni(ii) complexes viz. [Ni(hmpH)2(H2O) 2]Br2 (1), [Ni4(hmp)4(-OAc) 4] (2), [Ni2(-Br)2(5-ehmpH)4]Br 2·0.33MeCN·0.67H2O (3), [Ni(5-ehmpH) 3]Br2·0.33MeOH (4), [Ni4(5-ehmp) 4(H2O)4Br4] (5) and [Ni 4(5-ehmp)4(-OAc)2(OAc)2(H 2O)2] (6), all of which have different chemical compositions and structures. Complexes 2, 5 and 6, however, share a common cubane [Ni4O4] core in which the deprotonated alkoxypyridine serves as a bridge-chelate. The others (viz.1, 3, 4) are mono- or dinuclear with the alkoxypyridine remaining in its native acid form.

PHARMACEUTICAL COMPOUNDS

The invention provides a composition of matter which: ? (i) consists of at least 90 % by weight of an atropisomer (2A) and 0-10 % by weight of an atropisomer of formula (2B); or ? (ii) consists of at least 90 % by weight of an atropisomer (2B) and 0-10 %

PYRROLE DERIVATIVES AS PLK1 INHIBITORS

The invention provides compounds of the formula (3): or a pharmaceutically acceptable salt or tautomer thereof. The compounds are useful in the treatment of cancers.

PROCESS FOR THE PREPARATION OF 2,4- OR 2,5-PYRIDINEDICARBOXYLIC ACID AND COPOLYMERS DERIVED THEREFROM

The present invention relates to processes for the formation of pyridinedicarboxylic acid (PDCA), in particular, 2,4-pyridinedicarboxylic acid (2,4-PDCA) and 2,5-pyridinedicarboxylic acid (2,5-PDCA), and mono- and diester derivatives thereof, from 3,4-dihydroxybenzoic acid, via a biocatalytic reaction using, for example, a protocatechuate dioxygenase such as protocatechuate 4,5-dioxygenase or protocatechuate 2,3-dioxygenase, and a nitrogen source. The invention also relates to copolymers that comprise the pyridinedicarboxylic acid monomers and derivatives thereof, processes for the formation of the copolymers and uses for the copolymers.

A pair of highly biotolerated diamagnetic and paramagnetic iron(II) complexes displaying electroneutrality

A pair of structurally analogous macrocyclic iron(ii) complexes with a magnetic off-on relationship is reported that exhibit electroneutrality at neutral pH and high stability in physiological media. This has been achieved by external charge compensation using nicotinate pendent arms. No contact toxicity was observed for cells up to 4 mM for the low-spin and 2 mM for the high-spin complex. These results are a necessary precursor to the future design of turn-on probes with elevated biotolerance.

A Ca2+-, Mg2+-, and Zn2+-Based Dendritic Contractile Nanodevice with Two pH-Dependent Motional Functions

A contractile dendritic motional device is reported where metal ions with biological importance - Ca2+ (the main regulatory and signaling species of the natural muscles), Mg2+, and Zn2+ - initiate two kinds of motional functions. The first motional function is the metal-ion-induced contraction of a linear strand into a Z-shaped dinuclear complex, and the second one is the change of the height of Z-shaped complexes via transmetalation. By means of the pH-dependent counterligand tren, the two motional features of the machine can depend on alternate additions of acid and base. An optical response is associated with the conversion of the linear form (which is yellow) into the metalated Z-shaped one (which is red).

NITROIMIDAZOXADIAZOCINE COMPOUNDS

This invention relates to nitroimidazoxadiazocine compounds having the general Formula I, pharmaceutical compositions and uses of the same. The invention also relates to methods of making such nitroimidazoxadiazocine compounds of Formula I.

Towards the synthesis of substituted porphyrins by a pyridyl group bearing a reactive functionality

Pyridyl-substituted porphyrins bearing a reactive functionality were prepared via Suzuki cross-coupling reactions and resulted in very good yields. These compounds are precursors of new porphyrin architectures able to coordinate two metals: one in the porphyrin core and the second around the pyridyl moiety. During the coupling reactions, a higher reactivity of a chloro picolyl group was evidenced compared to a bromo function on the same reacting molecule.

Enantioselective Fujiwara-Moritani indole and pyrrole annulations catalyzed by chiral palladium(II)-NicOx complexes

The catalytic asymmetric Fujiwara-Moritani ring closures of several indole-and pyrrole-based cyclization precursors are reported. These unprecedented oxidative palladium(II)-catalyzed annulations allow for the formation of a stereogenic quaternary carbon atom, and decent levels of enantiocontrol are seen in 5-exo-trig cyclizations (54% ee for an indole and 76% ee for a pyrrole) while 6-exo-trig ring closures afford essentially racemic material. Novel oxazoline ligands with a nicotine platform (NicOx) are pivotal for good catalytic turnover as conventional PyOx ligands failed to produce acceptable chemical yields. The preparation of these NicOx ligands as well as the syntheses of the cyclization precursors are described in detail.