(S)-1-(6-bromo-3-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)ethanaminium (S)-2-hydroxy-2-phenylacetate

Base Information

Chemical Name:(S)-1-(6-bromo-3-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)ethanaminium (S)-2-hydroxy-2-phenylacetate
CAS No.:1262441-67-7
Molecular Formula:C₈H₈O₃*C₉H₁₀BrN₃OS
Molecular Weight:440.318
Hs Code.:

Synonyms:(S)-1-(6-bromo-3-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)ethanaminium (S)-2-hydroxy-2-phenylacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-(6-bromo-3-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)ethanaminium (S)-2-hydroxy-2-phenylacetate

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of (S)-1-(6-bromo-3-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)ethanaminium (S)-2-hydroxy-2-phenylacetate

There total 3 articles about (S)-1-(6-bromo-3-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)ethanaminium (S)-2-hydroxy-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.3%

: 1262441-63-3
(±)-7-(1-aminoethyl)-6-bromo-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one

: 17199-29-0
(S)-Mandelic acid

: 1262441-67-7
(S)-1-(6-bromo-3-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)ethanaminium (S)-2-hydroxy-2-phenylacetate

Guidance literature:: In isopropyl alcohol; for 0.583333h; Reflux;

Reference yield:

: 105983-77-5
methyl 4-bromo-3-oxopentanoate

: 1262441-67-7
(S)-1-(6-bromo-3-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)ethanaminium (S)-2-hydroxy-2-phenylacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: polyphosphoric acid / 70 - 78 °C / Inert atmosphere

2.1: N-Bromosuccinimide / acetonitrile / 0.33 h / 50 °C / Inert atmosphere

3.1: sodium azide / N,N-dimethyl-formamide / 0.83 h

4.1: sodium iodide / methanol / 0.17 h / 20 °C

4.2: 0.33 h / 5 - 25 °C

5.1: isopropyl alcohol / 0.58 h / Reflux

With N-Bromosuccinimide; sodium azide; sodium iodide; In methanol; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 30414-53-0
methyl propanoyl acetate

: 1262441-67-7
(S)-1-(6-bromo-3-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)ethanaminium (S)-2-hydroxy-2-phenylacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; bromine / dichloromethane / Cooling with ice

2.1: polyphosphoric acid / 70 - 78 °C / Inert atmosphere

3.1: N-Bromosuccinimide / acetonitrile / 0.33 h / 50 °C / Inert atmosphere

4.1: sodium azide / N,N-dimethyl-formamide / 0.83 h

5.1: sodium iodide / methanol / 0.17 h / 20 °C

5.2: 0.33 h / 5 - 25 °C

6.1: isopropyl alcohol / 0.58 h / Reflux

With N-Bromosuccinimide; sodium azide; bromine; sodium iodide; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;