(E)-3-(4-((6-hydroxy-2-(4-(trifluoromethyl)phenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid

Base Information

Chemical Name:(E)-3-(4-((6-hydroxy-2-(4-(trifluoromethyl)phenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid
CAS No.:1622307-15-6
Molecular Formula:C₂₄H₁₅F₃O₄S
Molecular Weight:456.442
Hs Code.:

Synonyms:(E)-3-(4-((6-hydroxy-2-(4-(trifluoromethyl)phenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid

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Chemical Property of (E)-3-(4-((6-hydroxy-2-(4-(trifluoromethyl)phenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid

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Technology Process of (E)-3-(4-((6-hydroxy-2-(4-(trifluoromethyl)phenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid

There total 7 articles about (E)-3-(4-((6-hydroxy-2-(4-(trifluoromethyl)phenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1622308-36-4
(E)-tert-butyl 3-(4-((6-methoxy-2-(4-(trifluoromethyl)phenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylate

: 1622307-15-6
(E)-3-(4-((6-hydroxy-2-(4-(trifluoromethyl)phenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid

Guidance literature:: With boron tribromide; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 1622308-31-9
3-(4-bromophenoxy)-6-methoxybenzo[b]thiophene

: 1622307-15-6
(E)-3-(4-((6-hydroxy-2-(4-(trifluoromethyl)phenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation

2: 1-Bromo-4-fluorobenzene; Trimethylacetic acid; potassium carbonate; chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II) / N,N-dimethyl acetamide / 2 h / 150 °C / Microwave irradiation; Sealed tube

3: boron tribromide / dichloromethane / 1 h / 0 °C

With bis-triphenylphosphine-palladium(II) chloride; chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); boron tribromide; potassium carbonate; triethylamine; 1-Bromo-4-fluorobenzene; Trimethylacetic acid; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 1622308-34-2
(E)-tert-butyl 3-(4-((6-methoxybenzo[b]thiophen-3-yl)oxy)phenyl)acrylate

: 1622307-15-6
(E)-3-(4-((6-hydroxy-2-(4-(trifluoromethyl)phenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1-Bromo-4-fluorobenzene; Trimethylacetic acid; potassium carbonate; chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II) / N,N-dimethyl acetamide / 2 h / 150 °C / Microwave irradiation; Sealed tube

2: boron tribromide / dichloromethane / 1 h / 0 °C

With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); boron tribromide; potassium carbonate; 1-Bromo-4-fluorobenzene; Trimethylacetic acid; In dichloromethane; N,N-dimethyl acetamide;