(E)-tert-butyl 3-(4-((6-methoxybenzo[b]thiophen-3-yl)oxy)phenyl)acrylate

Base Information

Chemical Name:(E)-tert-butyl 3-(4-((6-methoxybenzo[b]thiophen-3-yl)oxy)phenyl)acrylate
CAS No.:1622308-34-2
Molecular Formula:C₂₂H₂₂O₄S
Molecular Weight:382.48
Hs Code.:

Synonyms:(E)-tert-butyl 3-(4-((6-methoxybenzo[b]thiophen-3-yl)oxy)phenyl)acrylate

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Chemical Property of (E)-tert-butyl 3-(4-((6-methoxybenzo[b]thiophen-3-yl)oxy)phenyl)acrylate

Chemical Property:

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Technology Process of (E)-tert-butyl 3-(4-((6-methoxybenzo[b]thiophen-3-yl)oxy)phenyl)acrylate

There total 5 articles about (E)-tert-butyl 3-(4-((6-methoxybenzo[b]thiophen-3-yl)oxy)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 1622308-31-9
3-(4-bromophenoxy)-6-methoxybenzo[b]thiophene

: 1622308-34-2
(E)-tert-butyl 3-(4-((6-methoxybenzo[b]thiophen-3-yl)oxy)phenyl)acrylate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In N,N-dimethyl-formamide; at 120 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1622308-30-8
3-(4-bromophenoxy)-6-methoxybenzo[b]thiophene 1,1-dioxide

: 1622308-34-2
(E)-tert-butyl 3-(4-((6-methoxybenzo[b]thiophen-3-yl)oxy)phenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / tetrahydrofuran; dichloromethane / 2 h / 75 °C

2: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 862081-99-0
2,3-dibromo-6-methoxybenzo[b]thiophene 1,1-dioxide

: 1622308-34-2
(E)-tert-butyl 3-(4-((6-methoxybenzo[b]thiophen-3-yl)oxy)phenyl)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / tetrahydrofuran / 18 h / 20 °C

2: sodium tetrahydroborate / dimethyl sulfoxide; methanol / 3 h / 20 °C

3: diisobutylaluminium hydride / tetrahydrofuran; dichloromethane / 2 h / 75 °C

4: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; diisobutylaluminium hydride; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;