phenyl 2-(benzyloxy)-3-(bis(tert-butoxycarbonyl)amino)-6-methyl-5-(trifluoromethoxy)benzoate

Base Information

Chemical Name:phenyl 2-(benzyloxy)-3-(bis(tert-butoxycarbonyl)amino)-6-methyl-5-(trifluoromethoxy)benzoate
CAS No.:1268463-96-2
Molecular Formula:C₃₂H₃₄F₃NO₈
Molecular Weight:617.619
Hs Code.:

Synonyms:phenyl 2-(benzyloxy)-3-(bis(tert-butoxycarbonyl)amino)-6-methyl-5-(trifluoromethoxy)benzoate

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Chemical Property of phenyl 2-(benzyloxy)-3-(bis(tert-butoxycarbonyl)amino)-6-methyl-5-(trifluoromethoxy)benzoate

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Technology Process of phenyl 2-(benzyloxy)-3-(bis(tert-butoxycarbonyl)amino)-6-methyl-5-(trifluoromethoxy)benzoate

There total 8 articles about phenyl 2-(benzyloxy)-3-(bis(tert-butoxycarbonyl)amino)-6-methyl-5-(trifluoromethoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1268463-95-1
phenyl 3-amino-2-(benzyloxy)-6-methyl-5-(trifluoromethoxy)benzoate

: 1268463-96-2
phenyl 2-(benzyloxy)-3-(bis(tert-butoxycarbonyl)amino)-6-methyl-5-(trifluoromethoxy)benzoate

Guidance literature:: With dmap; In N,N-dimethyl-formamide;

Reference yield:

: 191604-88-3
2-methoxy-5-(trifluoromethoxy)benzoic acid

: 1268463-96-2
phenyl 2-(benzyloxy)-3-(bis(tert-butoxycarbonyl)amino)-6-methyl-5-(trifluoromethoxy)benzoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2.1: dmap / dichloromethane / 20 °C

3.1: 2,2,6,6-tetramethyl-piperidine; N,N,N,N,-tetramethylethylenediamine; n-butyllithium / hexane; tetrahydrofuran / 0.75 h / -78 °C

3.2: 3 h / -78 - 20 °C

4.1: boron tribromide / dichloromethane / 4 h / -78 - -10 °C

5.1: nitric acid; tetrabutylammomium bromide / water; 1,2-dichloro-ethane / 20 h / 20 - 25 °C

6.1: potassium carbonate; potassium iodide / acetone / 4 h / Reflux

7.1: water; sodium dithionite / tetrahydrofuran / 16 h / 0 - 20 °C

8.1: dmap / N,N-dimethyl-formamide

With 2,2,6,6-tetramethyl-piperidine; dmap; n-butyllithium; sodium dithionite; oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; tetrabutylammomium bromide; water; nitric acid; boron tribromide; potassium carbonate; potassium iodide; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 191604-91-8
2-Methoxy-5-trifluoromethoxybenzoyl Chloride

: 1268463-96-2
phenyl 2-(benzyloxy)-3-(bis(tert-butoxycarbonyl)amino)-6-methyl-5-(trifluoromethoxy)benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap / dichloromethane / 20 °C

2.1: 2,2,6,6-tetramethyl-piperidine; N,N,N,N,-tetramethylethylenediamine; n-butyllithium / hexane; tetrahydrofuran / 0.75 h / -78 °C

2.2: 3 h / -78 - 20 °C

3.1: boron tribromide / dichloromethane / 4 h / -78 - -10 °C

4.1: nitric acid; tetrabutylammomium bromide / water; 1,2-dichloro-ethane / 20 h / 20 - 25 °C

5.1: potassium carbonate; potassium iodide / acetone / 4 h / Reflux

6.1: water; sodium dithionite / tetrahydrofuran / 16 h / 0 - 20 °C

7.1: dmap / N,N-dimethyl-formamide

With 2,2,6,6-tetramethyl-piperidine; dmap; n-butyllithium; sodium dithionite; N,N,N,N,-tetramethylethylenediamine; tetrabutylammomium bromide; water; nitric acid; boron tribromide; potassium carbonate; potassium iodide; In tetrahydrofuran; hexane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone;