191604-88-3

Basic information

• Product Name: 2-METHOXY-5-(TRIFLUOROMETHOXY)BENZOIC ACID
• Synonyms: RARECHEM AL BO 1035;2-METHOXY-5-(TRIFLUOROMETHOXY)BENZOIC ACID;3-TRIFLUOROMETHOXY-6-METHOXYBENZOIC ACID;Benzoic acid, 2-methoxy-5-(trifluoromethoxy)-
• CAS NO: 191604-88-3
• Molecular Formula: C₉H₇F₃O₄
• Molecular Weight: 236.14
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid
• Mol File: 191604-88-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 63-65°C
• Boiling Point: 283.7 °C at 760 mmHg
• Flash Point: 125.4 °C
• Appearance: white crystal powder
• Density: 1.419 g/cm³
• Vapor Pressure: 0.00146mmHg at 25°C
• Refractive Index: 1.476
• PKA: 3.71±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-METHOXY-5-(TRIFLUOROMETHOXY)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-5-(TRIFLUOROMETHOXY)BENZOIC ACID(191604-88-3)
• EPA Substance Registry System: 2-METHOXY-5-(TRIFLUOROMETHOXY)BENZOIC ACID(191604-88-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-43
• Safety Statements: 26-36/37/39-36/37
• Hazardous Substances Data: 191604-88-3(Hazardous Substances Data)

Usage

General Description

2-Methoxy-5-(trifluoromethoxy)benzoic acid is a chemical compound with the molecular formula C9H7F3O4. It is a white to off-white crystalline powder that is insoluble in water but soluble in organic solvents. 2-METHOXY-5-(TRIFLUOROMETHOXY)BENZOIC ACID is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block in the production of various other chemicals. The trifluoromethoxy group on the benzene ring provides unique chemical reactivity, making this compound valuable in organic synthesis. Additionally, it is important to handle this compound with care as it may cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C9H7F3O4/c1-15-7-3-2-5(16-9(10,11)12)4-6(7)8(13)14/h2-4H,1H3,(H,13,14)

Upstream product

• 124-38-9 carbon dioxide 
• 710-18-9 1-methoxy-4-(trifluoromethoxy)benzene 
• 145742-65-0 2-methoxy-5-(trifluoromethoxy)benzaldehyde 
• 7758-19-2 sodium chlorite 
• 10049-21-5 sodium dihydrogen phosphate monohydrate 
• 513-35-9 2-methyl-but-2-ene 
• 200956-14-5 2-bromo-1-methoxy-4-(trifluoromethoxy)benzene 

Downstream Products

• 191604-91-8 2-Methoxy-5-trifluoromethoxybenzoyl Chloride 
• 1268463-90-6 (4aS,11aR,12aS,13S)-3-(benzyloxy)-4a-(tert-butyldimethylsilyloxy)-13-(dimethylamino)-5-hydroxy-4,6-(dioxo-10-(trifluoromethoxy)-4,4a,6,11,11a,12,12a,13-octahydrotetraceno[2,3-d]isoxazol-7-yl)tert-butyl carbonate 
• 1268463-96-2 phenyl 2-(benzyloxy)-3-(bis(tert-butoxycarbonyl)amino)-6-methyl-5-(trifluoromethoxy)benzoate 
• 1268463-95-1 phenyl 3-amino-2-(benzyloxy)-6-methyl-5-(trifluoromethoxy)benzoate 
• 1268463-94-0 phenyl 2-(benzyloxy)-6-methyl-3-nitro-5-(trifluoromethoxy)benzoate 
• 1268463-93-9 phenyl 2-hydroxy-6-methyl-3-nitro-5-(trifluoromethoxy)benzoate 
• 1268463-89-3 phenyl 6-(tert-butoxycarbonyloxy)-2-methyl-3-(trifluoromethoxy)benzoate 
• 1268463-88-2 phenyl 6-hydroxy-2-methyl-3-(trifluoromethoxy)benzoate 
• 1268463-87-1 phenyl 6-methoxy-2-methyl-3-(trifluoromethoxy)benzoate 
• 1268463-86-0 phenyl 2-methoxy-5-(trifluoromethoxy)benzoate 
• 129644-57-1 TFMSA 

Relevant articles and documents

Metabolites of (+)-(2S,3S)-3(2-methoxy-5- trifluoromethoxybenzylamino)-2-phenyl-piperidine

Metabolites of (+)-(2S, 3S)-3-(2-methoxy-5-trifluoromethoxybenzylamino)-2-phenyl-piperidine, and use of same.

SUBSTITUTED 4-(1H-BENZIMIDAZOL-2-YL)[1,4]DIAZEPANES USEFUL FOR THE TREATMENT ALLERGIC DISEASES

The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4] diazepane derivatives of formula (1): and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease

The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4]diazepane derivatives of formula (1): and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.