Diphenylmethyl 2-<(3R,4R)-<(p-toluenesulfonyl)thio>-3-(phenoxyacetamido)-2-oxoazetidin-1-yl>-3-<(methanesulfonyl)oxy>-2-butenoate

Base Information

Chemical Name:Diphenylmethyl 2-<(3R,4R)-<(p-toluenesulfonyl)thio>-3-(phenoxyacetamido)-2-oxoazetidin-1-yl>-3-<(methanesulfonyl)oxy>-2-butenoate
CAS No.:157584-71-9
Molecular Formula:C₃₆H₃₄N₂O₁₀S₃
Molecular Weight:750.871
Hs Code.:

Synonyms:Diphenylmethyl 2-<(3R,4R)-<(p-toluenesulfonyl)thio>-3-(phenoxyacetamido)-2-oxoazetidin-1-yl>-3-<(methanesulfonyl)oxy>-2-butenoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Diphenylmethyl 2-<(3R,4R)-<(p-toluenesulfonyl)thio>-3-(phenoxyacetamido)-2-oxoazetidin-1-yl>-3-<(methanesulfonyl)oxy>-2-butenoate

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Technology Process of Diphenylmethyl 2-<(3R,4R)-<(p-toluenesulfonyl)thio>-3-(phenoxyacetamido)-2-oxoazetidin-1-yl>-3-<(methanesulfonyl)oxy>-2-butenoate

There total 1 articles about Diphenylmethyl 2-<(3R,4R)-<(p-toluenesulfonyl)thio>-3-(phenoxyacetamido)-2-oxoazetidin-1-yl>-3-<(methanesulfonyl)oxy>-2-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 124-63-0
methanesulfonyl chloride

: 57561-96-3
diphenylmethyl 3-hydroxy-2-<(3R,4R)-2-oxo-3-(phenoxyacetylamino)-4-(p-tolylsulfonylthio)-1-azetidinyl>-2-butenoate

: 157584-71-9
Diphenylmethyl 2-<(3R,4R)-<(p-toluenesulfonyl)thio>-3-(phenoxyacetamido)-2-oxoazetidin-1-yl>-3-<(methanesulfonyl)oxy>-2-butenoate

Guidance literature:: With TEA; In dichloromethane; for 2h;
DOI:10.1021/jo00096a045

Reference yield: 86.0%

: 157584-71-9
Diphenylmethyl 2-<(3R,4R)-<(p-toluenesulfonyl)thio>-3-(phenoxyacetamido)-2-oxoazetidin-1-yl>-3-<(methanesulfonyl)oxy>-2-butenoate

: 143159-86-8
Diphenylmethyl 2-<(3R,4R)-4-<(p-toluenesulfonyl)thio>-3-(phenoxyacetamido)-2-oxoazetidin-1-yl>-2,3-butadienoate

Guidance literature:: With TEA; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1021/jo00096a045

Reference yield:

: 157584-71-9
Diphenylmethyl 2-<(3R,4R)-<(p-toluenesulfonyl)thio>-3-(phenoxyacetamido)-2-oxoazetidin-1-yl>-3-<(methanesulfonyl)oxy>-2-butenoate

: 130516-10-8
diphenylmethyl (6R,7S)-7-(phenoxyacetamido)-3-ethylceph-3-em-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / TEA / CH₂Cl₂ / 1 h / Ambient temperature

2: 1.) CuI / 1.) THF, ether, 15 min, 2.) THF, -78 deg C, 20 min

With copper(l) iodide; TEA; In dichloromethane;
DOI:10.1021/jo00096a045