(1S,2S)-2-[(R)-4-(2,2-Diphenyl-ethyl)-1-(4-methoxy-benzyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester

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Chemical Name:(1S,2S)-2-[(R)-4-(2,2-Diphenyl-ethyl)-1-(4-methoxy-benzyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester
CAS No.:178684-64-5
Molecular Formula:C₃₇H₃₆N₂O₆
Molecular Weight:604.703
Hs Code.:

Synonyms:(1S,2S)-2-[(R)-4-(2,2-Diphenyl-ethyl)-1-(4-methoxy-benzyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester

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Chemical Property of (1S,2S)-2-[(R)-4-(2,2-Diphenyl-ethyl)-1-(4-methoxy-benzyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester

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Technology Process of (1S,2S)-2-[(R)-4-(2,2-Diphenyl-ethyl)-1-(4-methoxy-benzyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester

There total 6 articles about (1S,2S)-2-[(R)-4-(2,2-Diphenyl-ethyl)-1-(4-methoxy-benzyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 824-94-2
p-methoxybenzyl chloride

: 201851-27-6
(5SR)-5-((1S,2S)-2-carboxycycloprop-1-yl)-5-(2,2-diphenylethyl)imidazolidine-2,4-dione

: 178684-64-5
(1S,2S)-2-[(R)-4-(2,2-Diphenyl-ethyl)-1-(4-methoxy-benzyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester

: (1S,2S)-2-[(S)-4-(2,2-Diphenyl-ethyl)-1-(4-methoxy-benzyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester

Guidance literature:: With potassium hydrogencarbonate; In N,N-dimethyl-formamide; at 125 ℃;
DOI:10.1021/jm970498o

Reference yield:

: 96149-00-7
(1S,2S)-cyclopropane-1,2-dicarboxylic acid bis-(1R,2S,5R)-(5-isopropyl-2-methyl-cyclohexyl) ester

: 178684-64-5
(1S,2S)-2-[(R)-4-(2,2-Diphenyl-ethyl)-1-(4-methoxy-benzyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 5 N aq. NaOH / propan-2-ol / 70 °C

2: SOCl₂ / Ambient temperature

3: 1.) Zn(Cu), 2.) Pd(Ph₃P)4 / 1.) benzene, N,N-dimethylacetamide, 60 deg C, 3 h, 2.) benzene, N,N-dimethylacetamide, RT, 1 h

4: 1 N aq. NaOH / ethanol / 24 h / 55 °C

5: ethanol; H₂O / 48 h / 55 °C

6: 30 percent / KHCO₃ / dimethylformamide / 125 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; zinc copper; potassium hydrogencarbonate; In ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm970498o

Reference yield:

: 175221-03-1
(1S,2S)-cyclopropane-1,2-dicarboxylic acid mono-(1R,2S,5R)-(5-isopropyl-2-methyl-cyclohexyl) ester

: 178684-64-5
(1S,2S)-2-[(R)-4-(2,2-Diphenyl-ethyl)-1-(4-methoxy-benzyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂ / Ambient temperature

2: 1.) Zn(Cu), 2.) Pd(Ph₃P)4 / 1.) benzene, N,N-dimethylacetamide, 60 deg C, 3 h, 2.) benzene, N,N-dimethylacetamide, RT, 1 h

3: 1 N aq. NaOH / ethanol / 24 h / 55 °C

4: ethanol; H₂O / 48 h / 55 °C

5: 30 percent / KHCO₃ / dimethylformamide / 125 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; zinc copper; potassium hydrogencarbonate; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm970498o