(R)-4-Methyl-2-(4-(3-(methylsulfonyl)phenylamino)-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)pentanamide

Base Information

Chemical Name:(R)-4-Methyl-2-(4-(3-(methylsulfonyl)phenylamino)-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)pentanamide
CAS No.:1312691-57-8
Molecular Formula:C₂₀H₂₅N₅O₄S
Molecular Weight:431.516
Hs Code.:

Synonyms:(R)-4-Methyl-2-(4-(3-(methylsulfonyl)phenylamino)-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)pentanamide

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Chemical Property of (R)-4-Methyl-2-(4-(3-(methylsulfonyl)phenylamino)-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)pentanamide

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Technology Process of (R)-4-Methyl-2-(4-(3-(methylsulfonyl)phenylamino)-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)pentanamide

There total 7 articles about (R)-4-Methyl-2-(4-(3-(methylsulfonyl)phenylamino)-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1312691-58-9
(R)-methyl 6-(1-amino-4-methyl-1-oxopentan-2-ylamino)-4-cyano-2-(3-(methylsulfonyl)phenylamino)nicotinate

: 1312691-57-8
(R)-4-Methyl-2-(4-(3-(methylsulfonyl)phenylamino)-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)pentanamide

Guidance literature:: (R)-methyl 6-(1-amino-4-methyl-1-oxopentan-2-ylamino)-4-cyano-2-(3-(methylsulfonyl)phenylamino)nicotinate; With hydrogen; acetic acid; 20 % Pd(OH)2/C; In methanol; at 20 ℃; for 12h; under 760.051 Torr;

With sodium hydrogencarbonate; In methanol; water; at 20 ℃; for 16h;

Reference yield:

: 148493-37-2
2,6-dichloro-3-iodo-pyridine

: 1312691-57-8
(R)-4-Methyl-2-(4-(3-(methylsulfonyl)phenylamino)-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)pentanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C

1.2: 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 100 °C / 760.05 Torr / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 60 °C

5.1: 3-chloro-benzenecarboperoxoic acid / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

6.1: triethylamine / N,N-dimethyl-formamide / 14 h / 60 °C

7.1: hydrogen; acetic acid / 20 % Pd(OH)2/C / methanol / 12 h / 20 °C / 760.05 Torr

7.2: 16 h / 20 °C

With n-butyllithium; hydrogen; potassium carbonate; acetic acid; triethylamine; diisopropylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20 % Pd(OH)2/C; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1312690-81-5
methyl 2,6-dichloro-4-cyanonicotinate

: 1312691-57-8
(R)-4-Methyl-2-(4-(3-(methylsulfonyl)phenylamino)-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)pentanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 60 °C

2.1: 3-chloro-benzenecarboperoxoic acid / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

3.1: triethylamine / N,N-dimethyl-formamide / 14 h / 60 °C

4.1: hydrogen; acetic acid / 20 % Pd(OH)2/C / methanol / 12 h / 20 °C / 760.05 Torr

4.2: 16 h / 20 °C

With hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; 20 % Pd(OH)2/C; In methanol; N,N-dimethyl-formamide; acetonitrile;