(+)-(S)-2-Hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butansaeure

Base Information

Chemical Name:(+)-(S)-2-Hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butansaeure
CAS No.:103808-46-4
Molecular Formula:C₁₄H₁₈O₅
Molecular Weight:266.294
Hs Code.:

Synonyms:(+)-(S)-2-Hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butansaeure

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Chemical Property of (+)-(S)-2-Hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butansaeure

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Technology Process of (+)-(S)-2-Hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butansaeure

There total 15 articles about (+)-(S)-2-Hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butansaeure which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 53101-49-8,53174-06-4,53188-07-1,56305-04-5
(S)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid

: 103808-46-4
(+)-(S)-2-Hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butansaeure

Guidance literature:: With ammonium cerium(IV) nitrate; In water; acetonitrile; at 20 ℃; for 0.5h;
DOI:10.1248/cpb.50.1418

Reference yield:

: Ce(NH₄)2 (NO₃)6

: 103808-33-9
(S)-4-(2',5'-dimethoxy-3',4',6'-trimethylphenyl)-2-hydroxy-2-methylbutanoic acid

: 103808-46-4
(+)-(S)-2-Hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butansaeure

Guidance literature:: In water; acetonitrile;

Reference yield:

: 103808-42-0
2,5-dimethoxy-3,4,6-trimethylbenzaldehyde

: 103808-46-4
(+)-(S)-2-Hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butansaeure

Guidance literature:: Multi-step reaction with 7 steps

1: 4.9 g / KOH / methanol / 5 h / Heating

2: 0.75 g / 1N NaOH, H₂ / 5percent Pd/C / H₂O / 760 Torr

3: SOCl₂, pyridine

5: tetrahydrofuran / a) -78 deg C, 5h, b) -20 deg C, 16h

6: 28percent NaOH / ethanol / Ambient temperature

7: 111 mg / Ce(NH₄)2(NO₃)6 / acetonitrile; H₂O / 0.17 h / Ambient temperature

With pyridine; potassium hydroxide; sodium hydroxide; thionyl chloride; ammonium cerium(IV) nitrate; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water; acetonitrile;
DOI:10.1002/hlca.19900730431