103808-42-0Relevant articles and documents
PREPARATION AND USES OF REACTIVE OXYGEN SPECIES SCAVENGER DERIVATIVES
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, (2019/03/07)
Compounds of Formula (I) a or (I) b: including certain quinone derivatives, and the corresponding pharmaceutical compositions, which may serve to modulate ferroptosis in a subject. Also disclosed herein are the preparations of these compounds and pharmaceutical compositions and their potential uses in the manufacture of a medicament in reducing reactive oxygen species (ROS) in a cell and for preventing, treating, ameliorating certain related disorder or a disease.
SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES
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, (2018/10/15)
Methods of treating or suppressing oxidative stress diseases including mitochondrial diseases, impaired energy processing disorders, neurodegenerative diseases and diseases of aging are disclosed, as well as compounds useful in the methods of the invention, such as 2-substituted-p-quinone derivatives as disclosed herein.
Catalytic Asymmetric Cycloadditions of Silyl Nitronates Bearing α-Aryl Group
Jiang, Minghui,Feng, Lifei,Feng, Juanjuan,Jiao, Peng
supporting information, p. 2210 - 2213 (2017/05/12)
1,3-Dipolar cycloadditions of 2-alkylacroleins or atropaldehyde with triisopropylsilyl nitronates bearing an α-aryl group produced 3-aryl-2-isoxazolines having a chiral quaternary center in up to 94% ee and up to 88% yield with the aid of Corey’s oxazaborolidine catalyst. Specifically, the TIPS nitronate with an α-(p-methoxyphenyl) group gave mainly the 2-isoxazolines having an all-carbon quaternary center.
Total synthesis of (R, R, R)-γ-tocopherol through cu-catalyzed asymmetric 1,2-addition
Wu, Zhongtao,Harutyunyan, Syuzanna R.,Minnaard, Adriaan J.
, p. 14250 - 14255 (2015/03/18)
Based on the asymmetric copper-catalyzed 1,2-addition of Grignard reagents to ketones, (R, R, R)-γ-tocopherol has been synthesized in 36% yield over 12 steps (longest linear sequence). The chiral center in the chroman ring was constructed with 73% ee by the 1,2-addition of a phytol-derived Grignard reagent to an a-bromo enone prepared from 2,3-dimethylquinone.
Enzymatic substrates derived from phenoxazinone and their use as developer in detection of microorganisms with peptidase activity
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Page/Page column 15, (2009/12/07)
Novel enzymatic substrates of the general formula below: reaction media containing the same and their use for detecting and/or identifying and/or quantifying microorganisms expressing at least one peptidase activity.
Synthesis and testing of chromogenic phenoxazinone substrates for β-alanyl aminopeptidase
Zaytsev, Andrey V.,Anderson, Rosaleen J.,Bedernjak, Alexandre,Groundwater, Paul W.,Huang, Yongxue,Perry, John D.,Orenga, Sylvain,Roger-Dalbert, Celine,James, Arthur
, p. XX682-692 (2008/09/17)
Novel 7-N-(β-alanyl)aminophenoxazin-3-one salts 27a-d have been synthesized and tested as chromogenic substrates for β-alanyl aminopeptidase, which is present in Pseudomonas aeruginosa, the most common respiratory pathogen in patients with cystic fibrosis. The biological results show that 7-N-(β-alanyl)amino-1-pentylphenoxazin-3-one trifluoroacetate salt 27a is a chromogenic substrate for this bacterium, with a low degree of diffusion in nutrient media for growing bacterial cultures and a bright red colour, making it easily distinguishable from the agar background. This journal is The Royal Society of Chemistry.
Diels-alder trapping of ortho-quinone methides. A new entry to substituted xanthene- 1,4-diones
Giraud, Luc,Giraud, Anne
, p. 1153 - 1160 (2007/10/03)
Highly regioselective Diels-Alder reactions of a non-protected β-hydroxy quinone have been achieved after formation of chelated lithium alkoxides. In this report, we demonstrate on a model system, that the selectivity of reactions based on 1,3-dioxy-subst
SYNTHESIS AND SRN1 REACTION OF THE FIRST QUINONE-OXAZOLE BIOREDUCTIVE ALKYLATING AGENT
Crozet, Michel P.,Sabuco, Jean-Francois,Tamburlin, Isabelle,Barreau, Michel,Giraud, Luc,Vanelle, Patrice
, p. 45 - 54 (2007/10/02)
2-(2-Chloromethyloxazol-5-yl)-3,5,6-trimethyl-1,4-benzoquinone, the first compound of a new quinone-heterocyclic class of bioreductive alkylating agent, was prepared from trimethylhydroquinone in 8 steps and reacted by SRN1 reaction with lithiu
S(RN)1 reactions of a tetrasubstituted-1,4-benzoquinone
Crozet,Giraud,Sabuco,Vanelle,Barreau
, p. 4125 - 4128 (2007/10/02)
The C-alkylation reaction of 2-chloromethyl-3,5,6-trimethyl-1,4-benzoquinone by 2-nitropropane anion is shown to proceed by the S(RN)1 mechanism. This mechanism is confirmed by the inhibitory effects of dioxygen, p-dinitrobenzene, cupric chloride and di-t
Quinone derivatives, their production and use.
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, (2008/06/13)
Quinone derivatives represented by the general formula (wherein, R1 and R2, which are the same or different, refer to a hydrogen atom, methyl or methoxymethyl group, or R1 and R2 bind together to form-CH=CH-CH=CH-; R3 is a hydrogen atom or methyl group; R? is a nitrogen-containing heterocyclic group which may be substituted; R? is a hydrogen atom, methyl group, hydroxymethyl group which may be substituted, or a carboxyl group which may be (wherein, R' is a hydrogen atom or methyl group); n is an integer from 0 through 12, m is an integer from 0 through 3, and k is an integer from 0 through 7, providing that, when m is 2 or 3, Z and k are able to vary appropri-ately in the repeating unit shown in [ ] ), and the hydro-quinone derivatives thereof, are novel compounds, possess improvement effects of metabolism of poly unsaturated fatty acids, particularly two or more of inhibition of production of fatty acid peroxides, inhibition of production of metabo-lites in 5-lipoxygenase pathway, inhibition of thromboxane A? synthetase, thromboxane A? receptor antagonism and scavenging action of active oxygen species, and of use as drugs, such as antithrombotics, anti-vascular constriction agents, anti-asthma agent, antiallergic agents, therapeutics for psoriasis, agents for improvement in heart, brain and cardiovascular systems, therapeutics for nephritis, active oxygen-eliminating agents, anticancer agents, agents for improvement of control of arachidonate cascade products, etc.