{2-amino-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}(2-chlorophenyl)methanone

Base Information

Chemical Name:{2-amino-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}(2-chlorophenyl)methanone
CAS No.:1361414-09-6
Molecular Formula:C₁₇H₁₀ClF₃N₂OS
Molecular Weight:382.793
Hs Code.:

Synonyms:{2-amino-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}(2-chlorophenyl)methanone

Suppliers and Price of {2-amino-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}(2-chlorophenyl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of {2-amino-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}(2-chlorophenyl)methanone

Chemical Property:

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Technology Process of {2-amino-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}(2-chlorophenyl)methanone

There total 7 articles about {2-amino-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}(2-chlorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361414-06-3
N-[(bis{[4-(methyloxy)phenyl]methyl}amino)carbonothioyl]-3-(trifluoromethyl)benzamide

: 5000-66-8
2-chlorophenacyl bromide

: 1361414-09-6
{2-amino-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}(2-chlorophenyl)methanone

Guidance literature:: In N,N-dimethyl-formamide; at 85 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: C₃₃H₂₆ClF₃N₂O₃S

: 1361414-09-6
{2-amino-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}(2-chlorophenyl)methanone

Guidance literature:: With trifluoroacetic acid; at 80 ℃; for 8h;
DOI:10.1016/j.bmcl.2018.03.001

Reference yield:

: 2251-65-2
3-(Trifluoromethyl)benzoyl chloride

: 1361414-09-6
{2-amino-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}(2-chlorophenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetone / 2 h / 0 °C

1.2: 1 h / 0 °C

2.1: N,N-dimethyl-formamide / 0.5 h / 85 °C / Inert atmosphere

In N,N-dimethyl-formamide; acetone;