N-(p-methoxyphenyl)-3-[(1-tert-butoxycarbonyl)pyrrole-2-yl]-2,2-difluoro-3-hydroxypropionamide

Base Information

Chemical Name:N-(p-methoxyphenyl)-3-[(1-tert-butoxycarbonyl)pyrrole-2-yl]-2,2-difluoro-3-hydroxypropionamide
CAS No.:171252-14-5
Molecular Formula:C₁₉H₂₂F₂N₂O₅
Molecular Weight:396.391
Hs Code.:

Synonyms:N-(p-methoxyphenyl)-3-[(1-tert-butoxycarbonyl)pyrrole-2-yl]-2,2-difluoro-3-hydroxypropionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(p-methoxyphenyl)-3-[(1-tert-butoxycarbonyl)pyrrole-2-yl]-2,2-difluoro-3-hydroxypropionamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(p-methoxyphenyl)-3-[(1-tert-butoxycarbonyl)pyrrole-2-yl]-2,2-difluoro-3-hydroxypropionamide

There total 3 articles about N-(p-methoxyphenyl)-3-[(1-tert-butoxycarbonyl)pyrrole-2-yl]-2,2-difluoro-3-hydroxypropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 161282-57-1
N-tert-butoxycarbonylpyrrole-2-carboxaldehyde

: 171252-14-5
N-(p-methoxyphenyl)-3-[(1-tert-butoxycarbonyl)pyrrole-2-yl]-2,2-difluoro-3-hydroxypropionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / zinc / tetrahydrofuran / 0.25 h / Heating

2: 1M aq. NaOH / ethanol / 0.5 h

3: diisopropylethylamine, BOP-Cl / CH₂Cl₂ / 2 h / Ambient temperature

With sodium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1248/cpb.45.1793

Reference yield:

: 171252-15-6
2-(2-Ethoxycarbonyl-2,2-difluoro-1-hydroxy-ethyl)-pyrrole-1-carboxylic acid tert-butyl ester

: 171252-14-5
N-(p-methoxyphenyl)-3-[(1-tert-butoxycarbonyl)pyrrole-2-yl]-2,2-difluoro-3-hydroxypropionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1M aq. NaOH / ethanol / 0.5 h

2: diisopropylethylamine, BOP-Cl / CH₂Cl₂ / 2 h / Ambient temperature

With sodium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;
DOI:10.1248/cpb.45.1793

Reference yield:

: 104-94-9
4-methoxy-aniline

: Sodium; 3-(1-tert-butoxycarbonyl-1H-pyrrol-2-yl)-2,2-difluoro-3-hydroxy-propionate

: 171252-14-5
N-(p-methoxyphenyl)-3-[(1-tert-butoxycarbonyl)pyrrole-2-yl]-2,2-difluoro-3-hydroxypropionamide

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h; Yield given; Ambient temperature;
DOI:10.1248/cpb.45.1793