Ethyl 4-((5-bromopyrimidin-2-yl)(methyl)amino)-1-methylcyclohexanecarboxylate

Base Information

Chemical Name:Ethyl 4-((5-bromopyrimidin-2-yl)(methyl)amino)-1-methylcyclohexanecarboxylate
CAS No.:1372547-79-9
Molecular Formula:C₁₅H₂₂BrN₃O₂
Molecular Weight:356.263
Hs Code.:

Synonyms:Ethyl 4-((5-bromopyrimidin-2-yl)(methyl)amino)-1-methylcyclohexanecarboxylate

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Chemical Property of Ethyl 4-((5-bromopyrimidin-2-yl)(methyl)amino)-1-methylcyclohexanecarboxylate

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Technology Process of Ethyl 4-((5-bromopyrimidin-2-yl)(methyl)amino)-1-methylcyclohexanecarboxylate

There total 5 articles about Ethyl 4-((5-bromopyrimidin-2-yl)(methyl)amino)-1-methylcyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1372547-78-8
Ethyl 4-((5-bromopyrimidin-2-yl)-amino)-1-methylcyclohexanecarboxylate

: 74-88-4
methyl iodide

: 1372547-79-9
Ethyl 4-((5-bromopyrimidin-2-yl)(methyl)amino)-1-methylcyclohexanecarboxylate

Guidance literature:: Ethyl 4-((5-bromopyrimidin-2-yl)-amino)-1-methylcyclohexanecarboxylate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.166667h;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 65 ℃;

Reference yield:

: 51498-33-0
ethyl 4-amino-1-cyclohexanecarboxylate

: 1372547-79-9
Ethyl 4-((5-bromopyrimidin-2-yl)(methyl)amino)-1-methylcyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / toluene / Reflux

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

2.2: -78 - 20 °C

3.1: hydrazine hydrate / ethanol / 80 °C / Cooling with ice

4.1: N-ethyl-N,N-diisopropylamine / ethanol / 80 °C / Cooling with ice

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C

5.2: 0 - 65 °C

With hydrazine hydrate; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; ethanol; toluene; mineral oil;

Reference yield:

: 1776-53-0
4-aminocyclohexanecarboxylic acid

: 1372547-79-9
Ethyl 4-((5-bromopyrimidin-2-yl)(methyl)amino)-1-methylcyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 80 °C / Cooling with ice

2.1: triethylamine / toluene / Reflux

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

3.2: -78 - 20 °C

4.1: hydrazine hydrate / ethanol / 80 °C / Cooling with ice

5.1: N-ethyl-N,N-diisopropylamine / ethanol / 80 °C / Cooling with ice

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C

6.2: 0 - 65 °C

With thionyl chloride; hydrazine hydrate; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; ethanol; toluene; mineral oil;