1-cyclopropyl-3-(1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinyl)-2-(ethoxymethylene)-1,3-propanedione

Base Information

Chemical Name:1-cyclopropyl-3-(1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinyl)-2-(ethoxymethylene)-1,3-propanedione
CAS No.:1270001-21-2
Molecular Formula:C₂₅H₂₂N₂O₄
Molecular Weight:414.461
Hs Code.:

Synonyms:1-cyclopropyl-3-(1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinyl)-2-(ethoxymethylene)-1,3-propanedione

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Chemical Property of 1-cyclopropyl-3-(1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinyl)-2-(ethoxymethylene)-1,3-propanedione

Chemical Property:

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Technology Process of 1-cyclopropyl-3-(1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinyl)-2-(ethoxymethylene)-1,3-propanedione

There total 6 articles about 1-cyclopropyl-3-(1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinyl)-2-(ethoxymethylene)-1,3-propanedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1270001-17-6
1-cyclopropyl-3-(1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinyl)-1,3-propanedione

: 122-51-0
orthoformic acid triethyl ester

: 1270001-21-2
1-cyclopropyl-3-(1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinyl)-2-(ethoxymethylene)-1,3-propanedione

Guidance literature:: With acetic anhydride; at 110 ℃; for 4h; Inert atmosphere;

Reference yield:

: N-phenylbenzenecarboximidamide, sodium salt

: 1270001-21-2
1-cyclopropyl-3-(1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinyl)-2-(ethoxymethylene)-1,3-propanedione

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium chloride / acetonitrile / 2 h / Reflux

2.1: pyridine; lithium iodide / 24 h / Reflux

2.2: pH 7

3.1: phosphorus pentachloride / toluene / 6 h / Reflux; Inert atmosphere

4.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / -78 - -65 °C

4.2: -78 - -60 °C

4.3: -50 - 20 °C

5.1: acetic anhydride / 4 h / 110 °C / Inert atmosphere

With pyridine; n-butyllithium; phosphorus pentachloride; acetic anhydride; ammonium chloride; diisopropylamine; lithium iodide; In tetrahydrofuran; hexanes; toluene; acetonitrile;

Reference yield:

: 1270000-72-0
1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinecarboxylic acid

: 1270001-21-2
1-cyclopropyl-3-(1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinyl)-2-(ethoxymethylene)-1,3-propanedione

Guidance literature:: Multi-step reaction with 3 steps

1.1: phosphorus pentachloride / toluene / 6 h / Reflux; Inert atmosphere

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / -78 - -65 °C

2.2: -78 - -60 °C

2.3: -50 - 20 °C

3.1: acetic anhydride / 4 h / 110 °C / Inert atmosphere

With n-butyllithium; phosphorus pentachloride; acetic anhydride; diisopropylamine; In tetrahydrofuran; hexanes; toluene;