1-cyclopropyl-3-(1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinyl)-1,3-propanedione

Base Information

Chemical Name:1-cyclopropyl-3-(1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinyl)-1,3-propanedione
CAS No.:1270001-17-6
Molecular Formula:C₂₂H₁₈N₂O₃
Molecular Weight:358.397
Hs Code.:

Synonyms:1-cyclopropyl-3-(1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinyl)-1,3-propanedione

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Chemical Property of 1-cyclopropyl-3-(1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinyl)-1,3-propanedione

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Technology Process of 1-cyclopropyl-3-(1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinyl)-1,3-propanedione

There total 4 articles about 1-cyclopropyl-3-(1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinyl)-1,3-propanedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 765-43-5
Cyclopropyl methyl ketone

: 1270001-18-7
1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinecarboxylic acid chloride

: 1270001-17-6
1-cyclopropyl-3-(1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinyl)-1,3-propanedione

Guidance literature:: Cyclopropyl methyl ketone; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinecarboxylic acid chloride; In tetrahydrofuran; at -78 ℃; for 1h;

With water; ammonium chloride; In tetrahydrofuran; at 20 ℃; for 0.25h;

Reference yield:

: N-phenylbenzenecarboximidamide, sodium salt

: 1270001-17-6
1-cyclopropyl-3-(1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinyl)-1,3-propanedione

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium chloride / acetonitrile / 2 h / Reflux

2.1: pyridine; lithium iodide / 24 h / Reflux

2.2: pH 7

3.1: phosphorus pentachloride / toluene / 6 h / Reflux; Inert atmosphere

4.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / -78 - -65 °C

4.2: -78 - -60 °C

4.3: -50 - 20 °C

With pyridine; n-butyllithium; phosphorus pentachloride; ammonium chloride; diisopropylamine; lithium iodide; In tetrahydrofuran; hexanes; toluene; acetonitrile;

Reference yield:

: 1270000-72-0
1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinecarboxylic acid

: 1270001-17-6
1-cyclopropyl-3-(1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinyl)-1,3-propanedione

Guidance literature:: Multi-step reaction with 2 steps

1.1: phosphorus pentachloride / toluene / 6 h / Reflux; Inert atmosphere

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / -78 - -65 °C

2.2: -78 - -60 °C

2.3: -50 - 20 °C

With n-butyllithium; phosphorus pentachloride; diisopropylamine; In tetrahydrofuran; hexanes; toluene;