(2R,3S,4R,5R)-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxy-2-(2-phenyl-1,3-dioxan-5-yloxy)tetrahydrofuran-3-yl benzoate

Base Information

Chemical Name:(2R,3S,4R,5R)-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxy-2-(2-phenyl-1,3-dioxan-5-yloxy)tetrahydrofuran-3-yl benzoate
CAS No.:1612138-71-2
Molecular Formula:C₂₆H₃₀O₉
Molecular Weight:486.519
Hs Code.:

Synonyms:(2R,3S,4R,5R)-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxy-2-(2-phenyl-1,3-dioxan-5-yloxy)tetrahydrofuran-3-yl benzoate

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Chemical Property of (2R,3S,4R,5R)-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxy-2-(2-phenyl-1,3-dioxan-5-yloxy)tetrahydrofuran-3-yl benzoate

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Technology Process of (2R,3S,4R,5R)-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxy-2-(2-phenyl-1,3-dioxan-5-yloxy)tetrahydrofuran-3-yl benzoate

There total 9 articles about (2R,3S,4R,5R)-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxy-2-(2-phenyl-1,3-dioxan-5-yloxy)tetrahydrofuran-3-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1612138-70-1
(2R,3R,4S,5S)-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-(4-oxopentanoyloxy)-2-(2-phenyl-1,3-dioxan-5-yloxy)tetrahydrofuran-3-yl benzoate

: 1612138-71-2
(2R,3S,4R,5R)-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxy-2-(2-phenyl-1,3-dioxan-5-yloxy)tetrahydrofuran-3-yl benzoate

Guidance literature:: With hydrazinium monoacetate; In methanol; dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/j.tet.2014.04.069

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 1612138-71-2
(2R,3S,4R,5R)-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxy-2-(2-phenyl-1,3-dioxan-5-yloxy)tetrahydrofuran-3-yl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / dichloromethane

2.1: N-iodo-succinimide / dichloromethane / 0.5 h / 0 °C / Molecular sieve; Inert atmosphere

2.2: 2 h / 0 °C / Molecular sieve; Inert atmosphere

3.1: hydrazinium monoacetate / dichloromethane; methanol / 3 h / 20 °C

With N-iodo-succinimide; hydrazinium monoacetate; toluene-4-sulfonic acid; In methanol; dichloromethane;
DOI:10.1016/j.tet.2014.04.069

Reference yield:

: 1374632-99-1
(2R,3S,4R,5S)-4-(tert-butyldiphenylsilyloxy)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-5-(p-tolylthio)tetrahydrofuran-3-ol

: 1612138-71-2
(2R,3S,4R,5R)-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxy-2-(2-phenyl-1,3-dioxan-5-yloxy)tetrahydrofuran-3-yl benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3 h / 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

3.1: pyridine / 2 h / 0 - 20 °C

4.1: N-iodo-succinimide / dichloromethane / 0.5 h / 0 °C / Molecular sieve; Inert atmosphere

4.2: 2 h / 0 °C / Molecular sieve; Inert atmosphere

5.1: hydrazinium monoacetate / dichloromethane; methanol / 3 h / 20 °C

With pyridine; dmap; N-iodo-succinimide; tetrabutyl ammonium fluoride; hydrazinium monoacetate; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.tet.2014.04.069