(2S,3S,4R,5S)-4-(tert-butyldiphenylsilyloxy)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-5-(p-tolylthio)tetrahydrofuran-3-yl 4-oxopentanoate

Base Information

Chemical Name:(2S,3S,4R,5S)-4-(tert-butyldiphenylsilyloxy)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-5-(p-tolylthio)tetrahydrofuran-3-yl 4-oxopentanoate
CAS No.:1374633-02-9
Molecular Formula:C₃₇H₄₆O₇SSi
Molecular Weight:662.92
Hs Code.:

Synonyms:(2S,3S,4R,5S)-4-(tert-butyldiphenylsilyloxy)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-5-(p-tolylthio)tetrahydrofuran-3-yl 4-oxopentanoate

Suppliers and Price of (2S,3S,4R,5S)-4-(tert-butyldiphenylsilyloxy)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-5-(p-tolylthio)tetrahydrofuran-3-yl 4-oxopentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3S,4R,5S)-4-(tert-butyldiphenylsilyloxy)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-5-(p-tolylthio)tetrahydrofuran-3-yl 4-oxopentanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3S,4R,5S)-4-(tert-butyldiphenylsilyloxy)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-5-(p-tolylthio)tetrahydrofuran-3-yl 4-oxopentanoate

There total 4 articles about (2S,3S,4R,5S)-4-(tert-butyldiphenylsilyloxy)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-5-(p-tolylthio)tetrahydrofuran-3-yl 4-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1374632-99-1
(2R,3S,4R,5S)-4-(tert-butyldiphenylsilyloxy)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-5-(p-tolylthio)tetrahydrofuran-3-ol

: 123-76-2
levulinic acid

: 1374633-02-9
(2S,3S,4R,5S)-4-(tert-butyldiphenylsilyloxy)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-5-(p-tolylthio)tetrahydrofuran-3-yl 4-oxopentanoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.tet.2012.03.074

Reference yield:

: 848900-41-4
p-tolyl 5,6-O-isopropylidene-1-thio-β-D-galactofuranoside

: 1374633-02-9
(2S,3S,4R,5S)-4-(tert-butyldiphenylsilyloxy)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-5-(p-tolylthio)tetrahydrofuran-3-yl 4-oxopentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

2: dmap; dicyclohexyl-carbodiimide / 3 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/j.tet.2012.03.074

Reference yield:

: 920267-56-7
4-methylphenyl 1-thio-β-D-galactofuranoside

: 1374633-02-9
(2S,3S,4R,5S)-4-(tert-butyldiphenylsilyloxy)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-5-(p-tolylthio)tetrahydrofuran-3-yl 4-oxopentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid; copper(II) sulfate / 24 h / 20 °C / Inert atmosphere

2: 1H-imidazole; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

3: dmap; dicyclohexyl-carbodiimide / 3 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; sulfuric acid; copper(II) sulfate; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/j.tet.2012.03.074