(R)-1-(1-(2-(2-mehoxy-4-(trifluoromethyl)benzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)-2-phenylethylboronic acid

Base Information

Chemical Name:(R)-1-(1-(2-(2-mehoxy-4-(trifluoromethyl)benzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)-2-phenylethylboronic acid
CAS No.:1613134-37-4
Molecular Formula:C₂₂H₂₃BF₃N₅O₅
Molecular Weight:505.261
Hs Code.:

Synonyms:(R)-1-(1-(2-(2-mehoxy-4-(trifluoromethyl)benzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)-2-phenylethylboronic acid

Suppliers and Price of (R)-1-(1-(2-(2-mehoxy-4-(trifluoromethyl)benzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)-2-phenylethylboronic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-1-(1-(2-(2-mehoxy-4-(trifluoromethyl)benzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)-2-phenylethylboronic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-1-(1-(2-(2-mehoxy-4-(trifluoromethyl)benzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)-2-phenylethylboronic acid

There total 4 articles about (R)-1-(1-(2-(2-mehoxy-4-(trifluoromethyl)benzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)-2-phenylethylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1613134-56-7
1-[2-(2-methoxy-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid [(R)-2-phenyl-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.0²'⁶]dec-4-yl)ethyl]amide

: 1613134-37-4
(R)-1-(1-(2-(2-mehoxy-4-(trifluoromethyl)benzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)-2-phenylethylboronic acid

Guidance literature:: With hydrogenchloride; Dihydroxy-isobutyl-boran; In methanol; hexane; water; at 20 ℃;

Reference yield:

: 1613134-38-5
1-(2-((tert-butoxycarbonyl)amino)ethyl)-1H-1,2,3-triazole-4-carboxylic acid methyl ester

: 1613134-37-4
(R)-1-(1-(2-(2-mehoxy-4-(trifluoromethyl)benzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)-2-phenylethylboronic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

1.2: 20 °C

2.1: lithium hydroxide; water / methanol; tetrahydrofuran / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

4.1: hydrogenchloride; Dihydroxy-isobutyl-boran / methanol; water; hexane / 20 °C

With hydrogenchloride; Dihydroxy-isobutyl-boran; water; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1613134-53-4
1-[2-(2-methoxy-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid methyl ester

: 1613134-37-4
(R)-1-(1-(2-(2-mehoxy-4-(trifluoromethyl)benzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)-2-phenylethylboronic acid

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide; water / methanol; tetrahydrofuran / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

3: hydrogenchloride; Dihydroxy-isobutyl-boran / methanol; water; hexane / 20 °C

With hydrogenchloride; Dihydroxy-isobutyl-boran; water; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; hexane; water; N,N-dimethyl-formamide;