1-[2-(2-methoxy-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid

Base Information

• Chemical Name: 1-[2-(2-methoxy-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid
• CAS No.: 1613134-55-6
• Molecular Formula: C₁₄H₁₃F₃N₄O₄
• Molecular Weight: 358.277

Synonyms:1-[2-(2-methoxy-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid

Chemical Property of 1-[2-(2-methoxy-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of 1-[2-(2-methoxy-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid

There total 2 articles about 1-[2-(2-methoxy-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-[2-(2-methoxy-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid methyl ester (1613134-53-4) → 1-[2-(2-methoxy-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid (1613134-55-6)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

Reference yield:

1-(2-((tert-butoxycarbonyl)amino)ethyl)-1H-1,2,3-triazole-4-carboxylic acid methyl ester (1613134-38-5) → 1-[2-(2-methoxy-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid (1613134-55-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

1.2: 20 °C

2.1: lithium hydroxide; water / methanol; tetrahydrofuran / 20 °C

With water; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield: 66.0%

1-[2-(2-methoxy-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid (1613134-55-6) + (R)-2-phenyl-1-((3a5,45,65,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)ethanamine hydrochloride (178455-03-3) → 1-[2-(2-methoxy-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid [(R)-2-phenyl-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02'6]dec-4-yl)ethyl]amide (1613134-56-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃;

upstream raw materials:

1-(2-((tert-butoxycarbonyl)amino)ethyl)-1H-1,2,3-triazole-4-carboxylic acid methyl ester

1-[2-(2-methoxy-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid methyl ester

Downstream raw materials:

1-[2-(2-methoxy-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid [(R)-2-phenyl-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.0²'⁶]dec-4-yl)ethyl]amide

(R)-1-(1-(2-(2-mehoxy-4-(trifluoromethyl)benzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)-2-phenylethylboronic acid

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